20.500.12556/RUL-164680 Compensational role between cathepsins Cathepsins, a family of lysosomal peptidases, play a crucial role in maintaining cellular homeostasis by regulating protein turnover and degradation as well as many specific regulatory actions that are important for proper cell function and human health. Alterations in the activity and expression of cathepsins have been observed in many diseases such as cancer, inflammation, neurodegenerative disorders, bone remodelling-related conditions and others. These changes are not exclusively harmful, but rather appear to be a compensatory response on the lack of one cathepsin in order to maintain tissue integrity. The upregulation of specific cathepsins in response to the inhibition or dysfunction of other cathepsins suggests a fine-tuned system of proteolytic balance and understanding the compensatory role of cathepsins may improve therapeutic potential of cathepsin's inhibitors. Selectively targeting one cathepsin or modulating their activity could offer new treatment strategies for a number of diseases. This review emphasises the need for comprehensive research into cathepsin biology in the context of disease. The identification of the specific cathepsins involved in compensatory responses, the elucidation of the underlying molecular mechanisms and the development of targeted interventions could lead to innovative therapeutic approaches. lysosomal peptidases compensation bone resorption cancer inflammation neurodegeneration katepsini rak vnetje nevrodegenerativne bolezni true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-07 09:55:21 2024-11-07 09:55:27 2024-11-22 14:55:20 0000-00-00 00:00:00 2024 0 0 Str. 62-76 Vol. 226 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577 1638-6183 10.1016/j.biochi.2024.04.010 193579011 1-s2.0-S0300908424000853-main.pdf 1-s2.0-S0300908424000853-main.pdf 1 20CAE8071608BE8508298C28D618D1AB 8e1261679f9e2c81998d219d3da54f58f136f303385ba17b32a38227f704106e 29e88de9-9ce6-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195287 https://www.sciencedirect.com/science/article/pii/S0300908424000853 0 b24bf17b-9ce5-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195286 Fakulteta za farmacijo 0 0 0