20.500.12556/RUL-164601 Novel strategies in systemic and local administration of therapeutic monoclonal antibodies Monoclonal antibodies (mAbs) are an evolving class of biopharmaceuticals, with advancements evident across various stages of their development. While discovery, mAb chemical optimization, production and purification processes have been thoroughly reviewed, this paper aims to offer a summary of novel strategies in administration of mAbs. At present, systemic delivery of mAbs is available through parenteral administration routes with focus on subcutaneous administration. In addition, oriented toward patient-friendly therapy, other less invasive administration routes of mAbs, such as inhalation, nasal, transdermal, and oral administration, are explored. Literature data reveals the potential for local delivery of mAbs via inhalation, nasal, transdermal, intratumoral, intravitreal and vaginal administration, offering high efficacy with fewer systemic adverse effects. However, to date, only mAb medicines are available for intravitreal administration, mainly due to higher bioavailability, and an intranasal spray is authorised as a medical device. The review highlights the promising data in approval of novel administration routes, likely through inhalation, but further intensive research considering the current obstacles, is essential. biopharmaceuticals monoclonal antibodies delivery systems patient-friendly therapy subcutaneous administration biofarmacevtski izdelki monoklonska protitelesa pacientu prijazna terapija subkutana aplikacija dostavni sistemi true false true Angleški jezik Slovenski jezik Članek v reviji 2024-11-05 09:53:45 2024-11-05 09:53:50 2024-11-22 14:54:59 0000-00-00 00:00:00 2024 0 0 13 str. pt. A, art. 124877 Vol. 667 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.015.14 0378-5173 10.1016/j.ijpharm.2024.124877 213575427 1-s2.0-S0378517324011116-main.pdf 1-s2.0-S0378517324011116-main.pdf 1 29664A6A4DF2ECC193CAD38A6BF4D403 ec82e94946da32692b1d7913d7dff75a092f718249081c55c6a80af69fba5e33 885b5c33-9b53-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195146 https://www.sciencedirect.com/science/article/pii/S0378517324011116 1 251d706f-9b53-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=195145 Fakulteta za farmacijo 0 0 0