20.500.12556/RUL-163535 Personalization of thiopurine therapy current recommendations and future perspectives Despite great therapeutic advances in the field of biologics, small synthetic molecules such as thiopurines, including azathioprine, mercaptopurine, and thioguanine, remain an important therapeutic pillar in the treatment of inflammatory bowel disease, other autoimmune disorders, and cancer. This review presents the latest guidelines for thiopurine administration, highlighting the importance of individualized therapy guided by pharmacogenomics. It emphasizes dose adjustment based on nudix hydrolase 15 (NUDT15) and thiopurine S-methyltransferase (TPMT) genotype, alongside thiopurine S-methyltransferase activity and thiopurine metabolic profile. In addition, the article takes a critical look at emerging research in the field of thiopurine pharmacogenomics featuring novel genetic markers and technological developments in genetic testing. Finally, the potential of integrated approaches that combine genetic, metabolic, and clinical factors to further individualize thiopurine therapy is highlighted. thiopurines TPMT NUDT15 personalized medicine therapeutic drug monitoring tiopurini TPMT NUDT15 terapevtsko spremljanje zdravil personalizirana medicina true false true Angleški jezik Slovenski jezik Članek v reviji 2024-10-08 12:17:00 2024-10-08 12:17:06 2024-10-10 03:43:46 0000-00-00 00:00:00 2024 0 0 Str. 355-381 no. 3 Vol. 74 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61-027.552 1846-9558 10.2478/acph-2024-0030 206023171 Personalization-of-thiopurine-therapy-Current-recommendations-and-future-perspectives_(1).pdf Personalization-of-thiopurine-therapy-Current-recommendations-and-future-perspectives_(1).pdf 1 2663CFB851AEFC3C327FC1F19CD88ABF b3dd9e30bf0114f2a3353f75bcadbf03b1191adfb766965234eb4863250a0bb6 26ba4c4e-855f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193309 https://acta.pharmaceutica.farmaceut.org/wp-content/uploads/2024/09/35524.pdf 1 4c3b27e1-855e-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193303 https://sciendo.com/article/10.2478/acph-2024-0030 1 4c9aa855-855e-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193304 Fakulteta za farmacijo 0 0 0