20.500.12556/RUL-163494 Analytical evaluation and antioxidant activity of welected vegetable oils to support evidence-based use in dermal products This study presents an analytical and biological evaluation of selected vegetable oils and their unsaponifiable compounds,which are of crucial importance for the cosmetic and pharmaceutical industries, with the aim of ensuring their targeted use in dermalproducts. Methods: Vegetable oils were selected based on their dominant fatty acid composition: pomegranate seed oil (punicicacid), linseed oil (α-linolenic acid), coconut oil (lauric acid), olive oil (oleic acid), poppy seed oil (linoleic acid), linden seed oil (linoleicacid), and marigold seed oil (α-calendic acid). Pharmacopoeial chemical values, fatty acid profiles, and unsaponifiable compoundswere analysed. Antioxidant activity was measured using DPPH assay. Results: Chemical values indicated good oxidative status andminimal hydrolysis. Fatty acid analysis revealed expected compositions, with rare linden and marigold seed oils exhibiting distinctivefatty acid composition, featuring sterculic and α-calendic acids. Marigold seed oil showed the richest profile of unsaponifiable com-pounds. Antioxidant activity was highest in olive oil and lowest in coconut oil. No significant correlation was found between the fattyacid composition, unsaponifiable matter, and antioxidant activity suggesting the synergistic or antagonistic interactions of oilcomponents. Conclusion: The study highlights the complex interactions among oil components that influence antioxidant activity.These findings deepen the understanding of the complex mechanisms determining the antioxidant properties of vegetable oils,crucial for informed decisions in dermal product formulation as demand for natural, effective cosmetic and pharmaceutical ingre-dients rises. antioxidant activity Calendula fatty acid composition pharmacopoeial chemical values Tilia unsaponifiable compounds vegetable oil bioactivity antioksidativno delovanje ognjič sestava maščobnih kislin farmakopejske kemijske vrednosti tilija neumiljive spojine bioaktivnost maščobne kisline rastlinska olja antioksidativna učinkovitost true false true Angleški jezik Slovenski jezik Članek v reviji 2024-10-08 08:38:10 2024-10-08 08:38:17 2024-10-10 03:38:46 0000-00-00 00:00:00 2024 0 0 10 str. no. 9 Vol. 19 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 54.04:547.466.3+664.34 1555-9475 10.1177/1934578X241281245 210219011 poljsak-kocevar-glavac-2024-analytical-evaluation-and-antioxidant-activity-of-selected-vegetable-oils-to-support.pdf poljsak-kocevar-glavac-2024-analytical-evaluation-and-antioxidant-activity-of-selected-vegetable-oils-to-support.pdf 1 74ED6C0D705FE48FA1A413BECFC3DF35 cfb80bf313bddef3e32004ae4c0a67467a42ba605ffe90447875c89b34f40542 fefd2331-853f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193231 https://journals.sagepub.com/doi/epdf/10.1177/1934578X241281245 1 ba886874-853f-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=193230 Fakulteta za farmacijo 0 0 0