20.500.12556/RUL-163381 Titanium dioxide substrates as sensors for detection of platelets and extracellular particles from blood plasma Biosensors are pivotal in biomedical applications, particularly for disease detection, diagnosis, treatment, health management, and monitoring. Titanium dioxide (TiO2) is a prominent material for biosensors due to its biocompatibility, corrosion resistance, and availability in various nanostructured forms. This study explores the interaction of platelets and extracellular vesicles (EVs) with different TiO2 surface morphologies using flow cytometry (FCM) and scanning electron microscopy (SEM). Blood plasma samples were incubated with various TiO2 surfaces to evaluate particle counts and characteristics. FCM results indicated a higher abundance of platelets compared to EVs, with significant fragmentation observed post-centrifugation. SEM analysis confirmed platelet activation and fragmentation, with the microflowered TiO2 surface displaying fewer vesicles due to its rough topography. The findings suggest that while TiO2 surface structuring minimally impacts particle counts, it influences platelet and EV interactions, highlighting the need for advanced detection techniques and further investigation into surface interactions. cold gaseous plasma atmospheric pressure plasma plasma technology dental medicine extracellular vesicles surface treatment true false true Angleški jezik Ni določen Drugo 2024-10-04 14:44:57 2024-10-04 14:44:58 2024-10-09 03:48:48 0000-00-00 00:00:00 2024 0 0 Str. 92-101 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577:616.15 10.55295/PSL.11.2024.11 210339587 205044227 RAZ_Rawat_Niharika_2024.pdf RAZ_Rawat_Niharika_2024.pdf 1 2028564D8985EA2218FA623188FF266A 4946abd932f1007d909271d7e7ee77181e4aa0f8712c4ff2853f3c0d80e61761 4df04ee2-824e-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=192987 https://www.zf.uni-lj.si/images/zalozba/Sokratska_11/11_Rawat_Niharika.pdf 0 802c74be-824e-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=192988 Zdravstvena fakulteta Fakulteta za elektrotehniko 0 0 0