20.500.12556/RUL-162552 Antiphospholipid syndrome in children Antiphospholipid syndrome (APS) in children is a rare disease associated with significant morbidity and mortality. In comparison with APS in adults, pediatric APS has a more severe presentation with frequent recurrences of thrombotic events and a higher probability of life-threatening catastrophic APS. Nonthrombotic manifestations are also more common in the pediatric age group and can precede thrombosis. New classification criteria have been introduced recently and have not yet been assessed in pediatric patients with APS. In addition to anticoagulation drugs, other novel therapies have emerged including the use of B cell and complement inhibitors, especially in catastrophic APS. The purpose of this review is to provide a broad overview of aPL-related clinical manifestations in pediatric patients based on the analysis of published cohorts and data from the international pediatric APS registry. We also aim to illustrate APS in infants caused by transplacentally transferred maternal aPL, which is very rarely associated with acute thrombotic events in the perinatal period and more frequently with long-term neurodevelopmental abnormalities. catastrophic antiphospholipid syndrome children infants antiphospholipid syndrome systemic lupus erythematosus antiphospholipid antibodies thrombosis thrombocytopenia chorea lupus anticoagulants anticardiolipin antibodies anti-β2 glycoprotein I antibodies true false true Angleški jezik Ni določen Članek v reviji 2024-09-25 08:29:06 2024-09-25 08:29:12 2024-09-29 03:22:13 0000-00-00 00:00:00 2024 0 0 15 str. iss. 3, art. 101986 Vol. 38 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1532-1770 10.1016/j.berh.2024.101986 204888323 1-s2.0-S1521694224000573-main.pdf 1-s2.0-S1521694224000573-main.pdf 1 14F741FFE023363B2C9D900A5E1F65A7 25424af96eacd51cb2581c909f1d3f441aea74464efe009798982cab7a6db1e6 cf83659a-7b07-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=191951 https://www.sciencedirect.com/science/article/pii/S1521694224000573 0 b526d38d-7b07-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=191950 Medicinska fakulteta 0 0 0