20.500.12556/RUL-162191 2-Bromopyridines as versatile synthons for heteroarylated 2-pyridones via Ru(II)-mediated domino C–O/C–N/C–C bond formation reactions A novel methodology for the synthesis of 2-pyridones bearing a 2-pyridyl group on nitrogen and carbon atoms, starting from 2-bromopyridines, was developed employing a simple Ru(II)–KOPiv–Na$_2$CO$_3$ catalytic system. Unsubstituted 2-bromopyridine was successfully converted to the penta-heteroarylated 2-pyridone product using this method. Preliminary mechanistic studies revealed a possible synthetic pathway leading to the multi-heteroarylated 2-pyridone products, involving consecutive oxygen incorporation, a Buchwald–Hartwig-type reaction, and C–H bond activation. ruthenium catalysis heterocycles C-H activation pyridones 2-bromopyridines rutenijeva kataliza heterocikli C-H aktivacija piridoni 2-bromopiridini true false true Angleški jezik Slovenski jezik Članek v reviji 2024-09-19 13:49:31 2024-09-19 13:49:32 2024-09-23 03:36:18 0000-00-00 00:00:00 2024 0 0 13 str. iss. 18, art. 4418 Vol. 29 Sep. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.82 1420-3049 10.3390/molecules29184418 208047363 RAZ_Drev_Miha_2024.pdf RAZ_Drev_Miha_2024.pdf 1 C2D933EF17E9B3009058685F3EC066F9 cf419f7c9d4bb49aa98082c443bf6de5d334e1317a6b2a3cadf987a0658a4b99 e2ea4b86-767d-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=191369 https://www.mdpi.com/1420-3049/29/18/4418 1 21772344-767d-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=191368 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0