20.500.12556/RUL-161273 Koordinacijske spojine cinka(II) z metronidazolom Coordination compounds of zinc(II) with metronidazole V okviru diplomskega dela sem poskušala pripraviti nove koordinacijske spojine cinka(II) z metronidazolom. Metronidazol je derivat imidazola, v katerem je na en dušikov atom vezana skupina –CH$_2$CH$_2$OH, na ogljik (na položaju 2) v obroču je vezana metilna skupina, na ogljik (na položaju 5) v obroču pa je vezana nitro skupina. Običajno se metronidazol na kovine prehoda veže preko obročnega dušikovega atoma. Z metronidazolom sem reagirala različne spojine cinka(II): cinkov(II) acetat dihidrat, cinkov(II) klorid in cinkov(II) kinaldinat [Zn(quin)$_2$(H$_2$O)]. Reakcije so bile izvedene pri sobni temperaturi, segrevanju pri pogojih refluksa in v avtoklavu pri 105 °C. Iz cinkovega(II) acetata sem pridobila novo klaster spojino, [Zn$_7$O$_2$(OOCCH$_3$)$_{10}$(met)$_2$]·2CH$_3$CN. Ta je nastala pri vseh reakcijskih pogojih. Menjava acetonitrila s propionitrilom daje analogno spojino, [Zn$_7$O$_2$(OOCCH$_3$)$_{10}$(met)$_2$]·2CH$_3$CH$_2$CN. Iz cinkovega(II) klorida je bila izolirana že znana enojedrna spojina, [ZnCl$_2$(met)$_2$]. Sinteza koordinacijske spojine, ki bi vsebovala tako kinaldinatni ion kot metronidazol, ni uspela. Within the diploma work, we attempted to prepare new coordination compounds of zinc(II) with metronidazole. Metronidazole is an imidazole derivative with the CH$_2$CH$_2$OH moiety bound to one nitrogen atom, the methyl moiety at position 2 in the ring and a nitro functional group at position 5. Metronidazole usually coordinates to transition metal ions via ring nitrogen atom. Different zinc(II) compounds were reacted with metronidazole: zinc(II) acetate dihydrate, zinc(II) chloride and zinc(II) quinaldinate [Zn(quin)$_2$(H$_2$O)]. The reactions were carried out at ambient conditions, heating under reflux or heating at 105 °C in the autoclaves. Zinc(II) acetate afforded a novel cluster compound with the [Zn$_7$O$_2$(OOCCH$_3$)$_{10}$(met)$_2$]·2CH$_3$CN composition. The cluster formed at all reaction conditions. The replacement of acetonitrile with propionitrile afforded an analogous compound, [Zn$_7$O$_2$(OOCCH$_3$)$_{10}$(met)$_2$]·2CH$_3$CH$_2$CN. Zinc(II) chloride produced an already known mononuclear compound, [ZnCl$_2$(met)$_2$]. The synthesis of a zinc(II) coordination compound with both ligands, metronidazole and quinaldinate, was not met with success. koordinacijska kemija ligand cink(II) metronidazol coordination chemistry ligand zinc(II) metronidazole true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2024-09-09 10:13:30 2024-09-09 10:13:37 2024-09-20 13:08:00 0000-00-00 00:00:00 2024 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 24166 208337411 Lavric_Tinkara_-_Koordinacijske_spojine_cinka(II)_z_metronidazolom.pdf Lavric_Tinkara_-_Koordinacijske_spojine_cinka(II)_z_metronidazolom.pdf 1 D78366A7A8B26E246D397CF729348161 89d459eeb4771878aaef247a816a75c52521995df140445a7644f67675686c43 61a65d33-6e83-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=190168 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0