20.500.12556/RUL-161142 Računalniška simulacija dovajanja učinkovine za kemoterapijo prek tiksotropnega medija Computer simulation of chemotherapy active substance dosing through a thixotropic medium Kemoterapija spada med najbolj razširjene postopke zdravljenja rakavih obolenj, njen način delovanja pa je izvor dvoreznih učinkov. Del zdravila, ki ne deluje nad škodljivimi celicami, neizogibno prizadene zdravo tkivo; zmanjšanje območja delovanja bi imelo torej dvojno pozitiven učinek. Če ima zmes, v kateri se nahaja učinkovina, tiksotropen odziv na obremenitve, lahko omeji prekomerno širjenje zdravila in posledično omogoči večji nadzor nad vplivom učinkovine na tkivo. V delu je predstavljena izpeljava enostavnega splošnega modela za napoved časovno in krajevno odvisne razporeditve koncentracije učinkovine po vbrizgu. Primerjava newtonske in tiksotropne zmesi kaže na potencialne koristi induciranja nekonstantnih viskoznih lastnosti fluida, medtem ko parametrična analiza razodeva ključni pomen viskoznosti zmesi v neobremenjenem stanju pri oblikovanju specifične terapije za posamezen primer. Chemotherapy is one of the most widely used treatments for cancer, but its mode of action can lead to double-edged outcomes. The portion of the medication that does not target harmful cells inevitably affects healthy tissue; reducing the propagation would therefore have a doubly positive effect. If the mixture in which the active substance is located exhibits a thixotropic response to loads, it can limit the excessive spread of the medication and consequently allow for increased control over the effect of the active substance on the tissue. This work presents the derivation of a simple, general model for predicting the time- and location-dependent distribution of the concentration of the active substance after the injection. A comparison between Newtonian and thixotropic mixtures shows the potential benefits of inducing non-constant viscous fluid properties, while a parametric analysis reveals the crucial role played by the unloaded mixture viscosity in designing a case-specific therapy. kemoterapija tiksotropija viskoznost tkivo porozni medij chemotherapy thixotropy viscosity tissue porous medium true false false Slovenski jezik Angleški jezik Zaključna naloga 2024-09-07 08:31:37 2024-09-07 08:31:40 2024-11-21 11:15:42 0000-00-00 00:00:00 2024 0 0 XIII, 44 f. 2024 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 532.13:544.022.822:616-006(043.2) 265423 215929091 37065.pdf 37065.pdf 1 8C0E3ACAFB751E42C85F18D972C83D09 8e80890711ee2a17c7f63aa30d6fde009210af823d4930628817eca7ba28e70d d0430868-6ce2-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=190016 Fakulteta za strojništvo 0 0 0