20.500.12556/RUL-161035 Multifunctional roles of γ-enolase in the central nervous system more than a neuronal marker Enolase, a multifunctional protein with diverse isoforms, has generally been recognized for its primary roles in glycolysis and gluconeogenesis. The shift in isoform expression from α-enolase to neuron-specific γ-enolase extends beyond its enzymatic role. Enolase is essential for neuronal survival, differentiation, and the maturation of neurons and glial cells in the central nervous system. Neuron-specific γ-enolase is a critical biomarker for neurodegenerative pathologies and neurological conditions, not only indicating disease but also participating in nerve cell formation and neuroprotection and exhibiting neurotrophic-like properties. These properties are precisely regulated by cysteine peptidase cathepsin X and scaffold protein γ1-syntrophin. Our findings suggest that γ-enolase, specifically its C-terminal part, may offer neuroprotective benefits against neurotoxicity seen in Alzheimer's and Parkinson's disease. Furthermore, although the therapeutic potential of γ-enolase seems promising, the effectiveness of enolase inhibitors is under debate. This paper reviews the research on the roles of γ-enolase in the central nervous system, especially in pathophysiological events and the regulation of neurodegenerative diseases. γ-enolase neuronal marker neurotrophic-like factor neurodegeneration neuroprotection γ-enolaza nevronski markerji nevrotrofični faktorji nevrodegeneracija nevroprotekcija biomarkerji nevrologija true false true Angleški jezik Slovenski jezik Članek v reviji 2024-09-06 09:49:17 2024-09-06 09:49:21 2025-08-08 13:33:35 0000-00-00 00:00:00 2024 0 0 16 str. art. 61 Vol. 14 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2045-3701 10.1186/s13578-024-01240-6 197795331 s13578-024-01240-6_(1).pdf s13578-024-01240-6_(1).pdf 1 823A2AE8F685AFD82D12021214EC0096 f9a4ea6e3ace535e97b53234cc5006a0f0d91cffba8fd542d526263ee5288de7 31840584-6c25-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=189887 https://cellandbioscience.biomedcentral.com/articles/10.1186/s13578-024-01240-6 1 82dd13ab-6c24-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=189884 Fakulteta za farmacijo 0 0 0