20.500.12556/RUL-160778 Chloroimidazolium deoxyfluorination reagent with H$_2$F$_3$$^–$ anion as a sole fluoride source In the study, we introduce an air-stable NHC-based deoxyfluorination reagent ImCl[H$_2$F$_3$], offering a promising avenue for deoxyfluorination across various substrates. Reagent efficiently fluorinates benzyl alcohols, carboxylic acids, and P(V) compounds without external fluoride sources. A mechanistic study reveals a twostep process involving benzyl chloride as an intermediate, shedding light on the two-step reaction pathway. The Hammet plot provides insights into reaction mechanisms with different substrates, enhancing our understanding of this versatile deoxyfluorination method. alcohols anions organic acids pharmaceuticals reagents alkoholi anioni organske kisline farmacevtiki reagenti true false true Angleški jezik Slovenski jezik Članek v reviji 2024-09-04 13:23:23 2024-09-04 13:23:24 2025-08-08 13:20:30 0000-00-00 00:00:00 2024 0 0 Str. 10557-10561 iss. 15 Vol. 89 2 Aug. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 547.539.1 0022-3263 10.1021/acs.joc.4c00787 206205955 princic-et-al-2024-chloroimidazolium-deoxyfluorination-reagent-with-h2f3-anion-as-a-sole-fluoride-source.pdf princic-et-al-2024-chloroimidazolium-deoxyfluorination-reagent-with-h2f3-anion-as-a-sole-fluoride-source.pdf 1 8FF4E57D4C6D8FCCC771D80D0B176440 da843cddb943d27a0b04ce21a8b958be3da57e762e2fbfb3d229c93ad958102e 5a78bd4d-6ab0-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=189563 https://pubs.acs.org/doi/10.1021/acs.joc.4c00787 1 1950586e-6ab0-11ef-b232-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=189562 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0