20.500.12556/RUL-160174 Galectin-8 inhibition and functions in immune response and tumor biology Galectins are among organisms' most abundantly expressed lectins (carbohydrate-binding proteins) that specifically bind β-galactosides. They act not only outside the cell, where they bind to extracellular matrix glycans, but also inside the cell, where they have a significant impact on signaling pathways. Galectin-8 is a galectin family protein encoded by the LGALS8 gene. Its role is evident in both T- and B-cell immunity and in the innate immune response, where it acts directly on dendritic cells and induces some pro-inflammatory cytokines. Galectin-8 also plays an important role in the defense against bacterial and viral infections. It is known to promote antibacterial autophagy by recognizing and binding glycans present on the vacuolar membrane, thus acting as a danger receptor. The most important role of galectin-8 is the regulation of cancer growth, metastasis, tumor progression, and tumor cell survival. Importantly, the expression of galectins is typically higher in tumor tissues than in noncancerous tissues. In this review article, we focus on galectin-8 and its function in immune response, microbial infections, and cancer. Given all of these functions of galectin-8, we emphasize the importance of developing new and selective galectin-8 inhibitors and report the current status of their development. galectins galectin-8 galectin-8 inhibitors immune response tumor galektini galektin-8 zaviralci galektina-8 imunski odziv tumorji true false true Angleški jezik Slovenski jezik Članek v reviji 2024-08-22 11:48:30 2024-08-22 11:48:33 2024-08-23 04:11:38 0000-00-00 00:00:00 2024 0 0 Str. 2236-2265 iss. 5 Vol. 44 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-097:616-006 1098-1128 10.1002/med.22041 192485379 Medicinal_Research_Reviews_-_2024_-_Puric_-_Galectin‐8_inhibition_and_functions_in_immune_response_and_tumor_biology.pdf Medicinal_Research_Reviews_-_2024_-_Puric_-_Galectin‐8_inhibition_and_functions_in_immune_response_and_tumor_biology.pdf 1 1B946288E8E360D205A623A85016F73C 7240f2cd814c167456694f6787de7b8b778afdc6f552255357b30a6d59093f45 c9942cc7-606b-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188687 https://onlinelibrary.wiley.com/doi/10.1002/med.22041 1 7af74766-606b-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188684 Fakulteta za farmacijo 0 0 0