20.500.12556/RUL-160117 Dynamics of serum levels of TNF-α in a longitudinal follow-up study in 98 patients with juvenile idiopathic arthritis treated with anti-TNF-α biological drugs Objective: To determine the dynamics of serum levels of TNF-α in patients with juvenile idiopathic arthritis (JIA) treated with anti-TNF-α biological drugs and investigate their association with the disease activity. Methods: We conducted a single-centre, observational cohort study in 98 patients with JIA (30 boys, 68 girls, mean age 11.3 years) treated with anti-TNF-α biological drugs. Clinical examinations and laboratory assessments of serum levels of TNF-α were performed before starting therapy with biological drug and at 6-month intervals afterwards up to 2.5 years. Results: The analysis of serum levels of TNF-α in relation to the disease activity states showed the highest mean serum levels of TNF-α in patients on etanercept who had low disease activity states and in patients on adalimumab who had inactive disease. The correlation analysis in patients with JIA treated with etanercept or adalimumab showed a weak negative correlation between the serum levels of TNF-α and JADAS10 scores (p = 0.007), (r = – 0.177). Conclusion: The assessment of serum levels of TNF-α in children with JIA during treatment with etanercept or adalimumab is not a reliable biomarker of disease activity or immunological remission. Longitudinal measurement of TNF-α has no added clinical value in patients with JIA treated with anti-TNF-α biological drugs. adalimumab cytokines etanercept juvenile idiopathic arthritis tumour necrosis factor-alpha true false true Angleški jezik Ni določen Članek v reviji 2024-08-21 09:25:27 2024-08-21 09:25:31 2024-08-22 03:58:10 0000-00-00 00:00:00 2024 0 0 Str. 2287-2293 iss. 7 Vol. 43 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 0770-3198 10.1007/s10067-024-07012-4 203660291 s10067-024-07012-4.pdf s10067-024-07012-4.pdf 1 2D19D559F428C2EDCA38BD48C0857FDA 3c83a495aba4ec43e45616a66102f3a207625119627f3abbe1f0725cb84498bc a03efc97-5f8e-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188594 https://link.springer.com/article/10.1007/s10067-024-07012-4 0 79919bd1-5f8e-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188593 Medicinska fakulteta 0 0 0