20.500.12556/RUL-160104 Reference intervals of 24 trace elements in blood, plasma and erythrocytes for the Slovenian adult population Objectives: The aim of the present study was to establish the population- and laboratory-specific reference intervals (RIs) for the Slovenian adult population for 24 trace elements (TEs) in blood, plasma and erythrocytes and to evaluate the impact of gender, age, seafood consumption, smoking habits and amalgam fillings on TEs levels. Methods: TEs (Mn, Co, Cu, Zn, Se and Mo, Li, Be, V, Cr, Ni, Ga, As, Rb, Sr, Ag, Cd, Sn, Cs, Au, Hg, Tl, Pb and U) were determined in 192 a priori selected blood donors (107 women and 85 men, aged 18–65 years), using inductively coupled plasma mass spectrometry (ICP-MS) with the Octopole Reaction System. Participants filled out a questionnaire, and RIs were established according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for TEs. Results: Uniform RIs for non-essential and gender-specific for essential TEs in blood, plasma and erythrocytes were established. In our population, higher blood and plasma Cu, and erythrocyte Mn levels in women were found. In men, blood Zn, plasma Zn, Mn and Se, and erythrocyte Cu levels were higher. Zn levels were higher in 30–39 years age group. Pb and Sr increased with age. Smoking positively affected Cd, Pb, Cs and Rb; seafood consumption increased As, Hg and Zn; and amalgam increased Hg, Ag and Cu levels. Conclusions: Essential TEs were inside recommended levels, and the non-essential ones were far below critical levels. Established RIs will provide an important foundation for clinical diagnostics, safety erythrocyte transfusions assessment, toxicology and epidemiological studies. amalgam fillings essential trace elements non-essential trace elements gender inductively coupled plasma mass spectroscopy ICP-MS seafood smoking amalgamske zalivke esencialni elementi v sledovih nebistveni elementi v sledovih spol masna spektroskopija z induktivno sklopljeno plazmo ICP-MS morski sadeži kajenje klinična kemija diagnostika true false true Angleški jezik Slovenski jezik Članek v reviji 2024-08-20 15:31:36 2024-08-20 15:31:40 2024-08-24 04:06:49 0000-00-00 00:00:00 2024 0 0 Str. 946–957 iss. 5 Vol. 62 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-074 1437-4331 10.1515/cclm-2023-0731 173784835 10.1515_cclm-2023-0731_(5).pdf 10.1515_cclm-2023-0731_(5).pdf 1 39958F4A821A05788A7B180254F83FF2 f7eb370376a87d934c2a65bcee28f8d8c4608b69b1cb6ddac123ae049b0bcde0 93dcbdba-614e-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188807 https://www.degruyter.com/document/doi/10.1515/cclm-2023-0731/html 1 541451ab-5ef8-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188574 Fakulteta za farmacijo 0 0 0