20.500.12556/RUL-160002 Cu-alginate hydrogels in microfluidic systems a sustainable catalytic approach for click chemistry This work explores the innovative use of copper-alginate (Cu-alginate) hydrogels within microfluidic systems to catalyze dipolar cycloaddition reactions, emphasizing green chemistry principles and process intensification. Utilizing naturally occurring biopolymers, such as alginates, provides an environmentally friendly alternative to conventional catalyst supports due to their biocompatibility, biodegradability, and effective metal ion immobilization capabilities. The integration of these biopolymer-based catalysts into microfluidic devices allows for precise control over reaction conditions, leading to enhanced reaction kinetics and mass transfer efficiencies. Our results demonstrate that Cu-alginate hydrogels effectively catalyze the formation of 1,4-disubstituted 1,2,3-triazoles through [3 + 2] dipolar cycloaddition reactions with high regioselectivity and conversion. The microfluidic setup ensures rapid and efficient synthesis, surpassing traditional batch reaction methods in both reaction rate and environmental impact by reducing solvent usage and waste generation. Furthermore, the use of microfluidics contributes to the reproducibility and scalability of the synthesis process, important for industrial applications. The model-based design and its simulations have been employed to further understand and optimize the reaction system. Diffusion through the gel layer and catalytic reaction kinetics estimated from experimental data were included in the model, providing a theoretical foundation for a comprehensive process evaluation. This study not only advances the field of sustainable catalysis by demonstrating the practical utility of biopolymer-supported catalysts in microfluidic systems, but also sets the stage for further research into biopolymer applications in complex chemical syntheses. copper-alginate hydrogels microfluidic systems green chemistry coppper-catalyzed azide-alkyne cycloaddition (CuAAC) model based design click chemistry bakrovi-alginatni hidrogeli mikrofluidni sistemi zelena kemija azid-alkin cikloadicija katalizirana z bakrom (CuAAC) modeliranje procesa klik kemija true false true Angleški jezik Slovenski jezik Članek v reviji 2024-08-07 13:18:48 2024-08-07 13:18:50 2024-08-08 03:53:46 0000-00-00 00:00:00 2024 0 0 13 str. Vol. 6, art. 1434131 16 Jul. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 66.095.252.091.7:546.56:678 2673-2718 10.3389/fceng.2024.1434131 201934083 RAZ_Ramsak_Arijana_2024.pdf RAZ_Ramsak_Arijana_2024.pdf 1 0125ABE621603FFEB3B8440048F110F9 8998b2ff3ca3c765bee43865f7a3aa9ea372531e6d468250e19ee7f57387adae ea0cf786-54b4-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188329 https://www.frontiersin.org/journals/chemical-engineering/articles/10.3389/fceng.2024.1434131/full 1 ad0beec8-54ae-11ef-8f74-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=188322 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0