20.500.12556/RUL-159131 Men, testosterone and Covid‐19 Men have more severe Coronavirus disease 2019 (Covid‐19) outcomes and higher mortality rates than women, and it was suggested that testosterone levels might promote severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection and Covid‐19 severity. However, clinical studies have not supported this theory. Studies have consistently shown that serum testosterone concentrations during acute Covid‐19 in men are inversely proportional to the inflammatory cytokines and severity of illness. It is likely that lower testosterone concentrations in this setting are a result of acute Covid‐19 illness on the hypothalamic–pituitary–testicular axis. Clinical trials that attempted to lower testosterone concentrations further or block androgen signaling acutely during Covid‐19 in men did not result in improved Covid‐19 outcomes. Additionally, pre‐existing male hypogonadism, diagnosed before Covid‐19 pandemic, was found to be a risk factor for hospitalization from Covid‐19. In this review, we also discuss the preclinical and mechanistic studies that have evaluated the role of androgens in SARS‐CoV‐2 infection and illness. Finally, long‐term consequences of Covid‐19 on male reproductive health are reviewed. SARS‐CoV‐2 virus is known to infiltrate testis and induce orchitis in men, but it is unclear if Covid‐19 leads to an increase in incidence of male hypogonadism. Covid‐19 hypogonadism SARS‐CoV‐2 testes testosterone COVID-19 hipogonadizem SARS-CoV-2 moda testosteron true false true Angleški jezik Slovenski jezik Članek v reviji 2024-07-01 13:32:59 2024-07-01 13:33:03 2024-07-12 15:11:20 0000-00-00 00:00:00 2024 0 0 Str. 56-65 iss. 1 Vol. 100 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 0300-0664 10.1111/cen.14952 201676803 Clinical_Endocrinology_-_2023_-_Groti_Antonic_-_Men__testosterone_and_Covid‐19.pdf Clinical_Endocrinology_-_2023_-_Groti_Antonic_-_Men__testosterone_and_Covid‐19.pdf 1 A90C92F58D0B3322293E4BB84D0FC396 8443932d54df261b5ac0763ad56136bb9964539a296c776f8f9be9a054ea6d42 b354604a-37a3-11ef-a093-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=187039 https://onlinelibrary.wiley.com/doi/10.1111/cen.14952 0 ab3f6407-37a3-11ef-a093-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=187038 Medicinska fakulteta 0 0 0