20.500.12556/RUL-158608 Results of hematology, biochemistry and uninalysis in cats with chronic kidney disease research data underlying the article Rezultati hematoloških in biokemijskih preiskav ter urninograma pri mačkah s kronično boleznijo ledvic raziskovalni podatki, obravnavani v članku Chronic kidney disease (CKD) is characterized by chronic inflammation, which mediates the progressive replacement of functional nephrons by fibrotic tissue. Hemogram-derived inflammatory markers are known to serve as markers of pathological conditions; however, their diagnostic value in feline CKD is still unknown. The aim of this retrospective study was to investigate selected hemogram-derived inflammatory markers (neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR) and the systemic immune-inflammatory index (SII)) in cats at different clinical stages of CKD. Eighty-eight client-owned cats with CKD and thirty-two healthy control cats were included. Cats with CKD were divided into two groups: early CKD (IRIS stage 1 and 2; 62 cats) and progressed CKD (IRIS stage 3 and 4; 26 cats). The values of inflammatory markers were compared between the two CKD groups and the control group. All investigated hemogram-derived inflammatory markers were significantly ($p$ < 0.05) greater in cats with advanced CKD than in those in the other two groups. Additionally, we demonstrated a statistically significant weak to moderate correlation between serum urea, creatinine, selected hematologic and urinary parameters, and the investigated inflammatory markers in cats with CKD. Chronic inflammation can be easily and inexpensively assessed with hemogram-derived markers chronic kidney disease cats hemogram-derived inflammatory markers inflammation neutrophil-to-lymphocyte ratio monocyte-to-lymphocyte ratio platelet-to-lymphocyte ratio systemic immune-inflammatory index Kronična bolezen ledvic mačke hematološki markerji vnetja vnetje razmerje med nevtrofilnimi granulociti in limfociti razmerje med monociti in limfociti razmerje med trombociti in limfociti sistemski vnetni indeks true false false Angleški jezik Slovenski jezik Neznano 2024-06-17 15:47:12 2024-06-17 15:47:20 2025-04-16 13:32:29 0000-00-00 00:00:00 2024 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 ReadMe.docx ReadMe.docx 1 E7DD79399CF31D4837D62C7FFFE9A255 d7a2a5e661628078da7f5b4a20fd75cb00d81e4cadc813218b4b38a7a7f4c158 bcf2b61e-2cb0-11ef-b3fb-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=186292 Hemogram-Derived_Inflammatory_Markers_in_Cats_with_Chronic_Kidney_Disease.xlsx Hemogram-Derived_Inflammatory_Markers_in_Cats_with_Chronic_Kidney_Disease.xlsx 1 CB718E14701465EB1B76C7DF0808AA2B a4464a2dfa2e08875890f2d84ced33cb01d55cdba959b1c89aa55899ec668b9a c422813a-2cb0-11ef-b3fb-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=186293 Veterinarska fakulteta Meritve in testi 0 0 0