20.500.12556/RUL-158262 Sedative load and anticholinergic burden among older adults in Slovenia over a decade potential for optimization of pharmacotherapy This study investigates the 10-year trend in the sedative and anticholinergic burden among older adults in Slovenia, with the aim of identifying opportunities to optimize pharmacotherapy in this population. A retrospective drug utilization analysis was conducted based on a national anonymized database of dispensed prescriptions from 2009 to 2019. The study employed the sedative load model and the anticholinergic cognitive burden scale to assess the sedative and anticholinergic burden, respectively. The findings indicate that in 2019, 45.6 % and 40.8 % of older adults (≥ 65 years) used sedative and anticholinergic medications, respectively. A high sedative load and a clinically significant anticholinergic burden were observed in a considerable proportion of older adults (13.2 % and 11.2 %, respectively, in 2019). The age-standardized prevalence of sedative load and anticholinergic burden significantly decreased over the 10-year study period by 5.6 % and 1.7 %, respectively (absolute difference), while the prevalence of clinically significant anticholinergic burden remained stable. Notably, the age groups 85–89 years and above 90 years had an increase in the proportion of individuals with a clinically significant anticholinergic burden over the years. These results emphasize the need for targeted interventions, particularly in the oldest age groups, to promote safe and effective medication use among older adults. sedative load anticholinergic burden older adults pharmacotherapy optimization drug utilization study pharmacoepidemiology study farmakoterapija sedativna obremenitev antiholinergična obremenitev starejši odrasli optimizacija farmakoterapije študija uporabe zdravil farmakoepidemiološke študije true false true Angleški jezik Slovenski jezik Članek v reviji 2024-05-31 10:29:36 2024-05-31 10:29:42 2024-06-17 03:47:19 0000-00-00 00:00:00 2024 0 0 Str. 329-341 no. 2 Vol. 74 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615:616-085-053.88 1846-9558 10.2478/acph-2024-0017 191433475 32924.pdf 32924.pdf 1 0FEA92B856322E1370C935B4EAACB6A4 560ded2105be22f8d48f2819f41d724d7c38fb5e70994f05cfee24b54cd27a51 1ed25aae-1f28-11ef-850b-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=185793 https://acta.pharmaceutica.farmaceut.org/wp-content/uploads/2024/05/32924.pdf 1 ee95d66f-1f27-11ef-850b-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=185792 Fakulteta za farmacijo 0 0 0