20.500.12556/RUL-156320 The effect of taVNS on the cerebello-thalamo-cortical pathway a TMS study fMRI studies show activation of cerebellum during transcutaneous auricular vagal nerve stimulation (taVNS); however, there is no evidence whether taVNS induced activation of the cerebellum translates to the cerebellar closed loops involved in motor functions. We assessed the propensity of taVNS at 25 Hz (taVNS25) and 100 Hz (taVNS100) to modulate cerebello-thalamo-cortical pathways using transcranial magnetic stimulation. In our double blind within-subjects study thirty-two participants completed one visit during which cerebellar brain inhibition (CBI) was assessed at baseline (no stimulation) and in a randomized order during taVNS100, taVNS25, and sham taVNS (xVNS). Generalized linear mixed models with gamma distribution were built to assess the effect of taVNS on CBI. The estimated marginal means of linear trends during each taVNS condition were computed and compared in a pairwise fashion with Benjamini-Hochberg correction for multiple comparisons. CBI significantly increased during taVNS100 compared to taVNS25 and xVNS (p = 0.0003 and p = 0.0465, respectively). The taVNS current intensity and CBI conditioning stimulus intensity had no significant effect on CBI. taVNS has a frequency dependent propensity to modulate the cerebello-thalamo-cortical pathway. The cerebellum participates in closed-loop circuits involved in motor, cognitive, and affective operations and may serve as an entry for modulating effects of taVNS. vagal nerve stimulation transcutaneous electric nerve stimulation transcranial magnetic stimulation vagus nerve true false true Angleški jezik Ni določen Članek v reviji 2024-05-20 08:44:02 2024-05-20 08:44:07 2024-05-21 03:46:45 0000-00-00 00:00:00 2024 0 0 Str. 1013–1019 iss. 3 Vol. 23 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 61 1473-4230 10.1007/s12311-023-01595-5 179582979 s12311-023-01595-5.pdf s12311-023-01595-5.pdf 1 63A876D718A8D6F164C8BF266DE3F5F9 c50fb0d95897615dec6dc59dd94a23910916b2592fda05e0c1c8548ea8fed048 d0d71350-1674-11ef-b600-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183714 https://link.springer.com/article/10.1007/s12311-023-01595-5 1 5b4201b9-1674-11ef-b600-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183713 Medicinska fakulteta 0 0 0