20.500.12556/RUL-155884 Aggressive behavior in a bitch after deslorelin implant insertion Agresivno vedenje psice po vstavitvi implantata deslorelina In male dogs, long-acting gonadotropin-releasing hormone (GnRH) analogs are widely accepted as an alternative to surgical castration but are also used to sup-press and induce estrus in bitches (off label). Behavioral changes reported in bitches in association with the use of long-acting GnRH analogs have included male-like behav-ior associated with triggered estrus, increased food intake, enlargement of mammary glands and milk production, pseudopregnancy, and urinary incontinence. In male dogs, intra-species and rarely inter-species aggression may occur during the flare-up effect. However, at the time of downregulation, this behavior should no longer occur if it is tes-tosterone dependent.An intact, three-year-old female cocker spaniel with Addison’s disease was admitted to our clinic for consultation on spaying options because of pseudopregnancies followed by mastitis, which had to be treated with antibiotics, after her heat cycles. The owners were hesitant about surgical sterilization and therefore, deslorelin implant was inserted. Approximately one month after implantation, owners observed the onset of aggressive behavior, including incessant barking, extreme irritability, and aggression toward other dogs and towards family members. The behavior problems started to escalate and the owners were not able to handle her anymore. After removal of the implant, the observed aggression ceased, and the bitch returned to normal behavior.Although aggressive behavior toward other dogs and sometimes even toward owners has been observed after neutering or insertion of a deslorelin implant, this is the first report of extremely aggressive behavior toward owners and other dogs in a female dog after insertion of a 4.7 mg deslorelin implant. bitch aggression behavior deslorelin implant long-lasting GnRH psica agresija spolno vedenje deslorelinski implantat dolgo delujoči GnRH true false true Angleški jezik Slovenski jezik Članek v reviji 2024-04-23 13:03:15 2024-04-23 13:03:19 2024-04-24 04:20:22 0000-00-00 00:00:00 2023 0 0 str. 213-218 no. 4 Vol. 60 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 636.7:618.1 1580-4003 10.26873/SVR-1781-2023 193194755 https://slovetres.si/index.php/SVR/article/view/1781 1 18842892-0161-11ef-9b79-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183010 aggresive-zakosek.pdf aggresive-zakosek.pdf 1 90417DC3DEC7726B0BDE1103C4440FAF 5b281bc9be3c54ed2d8d271d804ad088f9ea176a0809383dfa9606dfc4b20a3e 5c32ba92-0161-11ef-9b79-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183012 Veterinarska fakulteta Slovenian veterinary research 0 0 0