20.500.12556/RUL-155882 The diagnostic accuracy of radiographic cardiac indices in the assessment of cardiomegaly and left atrial enlargement in rat with dilated cardiomyopathy: and experimental study Natančnost diagnostike radiografskih kazalcev srca pri ocenjevanju kardiomegalije in povečanja levega preddvora pri podganah z dilatativno kardiomiopatijo: eksperimentalna študija The purpose of this study was to determine the diagnostic value of the ver-tebral heart score (VHS), radiographic left atrial dimension (RLAD), and vertebral left atrial size (VLAS) in the radiographic evaluation of doxorubicin-induced dilated cardio-myopathy (DCM) in rats. The animals were allocated into two experimental groups, a DCM group (n=100), which received weekly injections of doxorubicin (2 mg/kg per dose intraperitoneally [ip]) over nine weeks, and a control group (n=18) receiving an appropri-ate volume of 0.9% saline ip. Radiographic cardiac indices (VHS, RLAD, VLAS) were measured two weeks after the final injection, and cardiac morphological parameters (heart weight [HW], heart weight:body weight ratio [HBW], and heart weight:tibial length ratio [HTL]) were determined after sacrifice in all surviving rats (17 control and 54 DCM). Correlations were calculated between the indices and parameters, as well as their sen-sitivity and specificity in detecting cardiomegaly and left atrial enlargement (LAE) with the three classifiers (HW≤0.96 g, HBW≤235, and HTL≤201). A powerful negative correla-tion was observed between the indices and parameters (rs≥-0.711, P<0.001). Area under the curve values were 0.989 for RL-VHS, 0.992 for DV-VHS, 0.971 for RLAD, and 0.948 for VLAS. The sensitivity and specificity of these indices in detecting cardiomegaly and LAE at the optimal cut-off values were 94.4% and 100%, respectively, at 8.8 vertebrae (v) for RL-VHS and DV-VHS, 96.3% and 94.1% at 1.4v for RLAD, and 94.4% and 88.2% at 2.1v for VLAS. Radiographic cardiac indices offer an accurate and repeatable method for predicting cardiomegaly and LAE in rats with DCM. dilated cardiomyopathy doxorubicin rat dilatativna kardiomiopatija doksorubicin podgana true false true Angleški jezik Slovenski jezik Članek v reviji 2024-04-23 12:57:45 2024-04-23 12:57:50 2024-04-24 04:20:22 0000-00-00 00:00:00 2023 0 0 str. 205-212 no. 4 Vol. 60 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 599.32:303.447.3:544.442:616.12-073.7 1580-4003 10.26873/SVR-1696-2023 188010755 diagnostic.pdf diagnostic.pdf 1 5B93C739BA643B2E74C8EF5036DC7841 03b41f7478220a1311097e623ed81e3484499b66aecd35db5507cd57ecd8962a f65b794d-0160-11ef-9b79-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183008 https://slovetres.si/index.php/SVR/article/view/1696 1 54717dfe-0160-11ef-9b79-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=183004 Veterinarska fakulteta Slovenian veterinary research 0 0 0