20.500.12556/RUL-155619 Prognostic impact of nutritional status on overall survival and health-related quality of life in men with advanced prostate cancer Purpose: Prognostic role of nutritional status (NS) in patients with metastatic castrate-resistant prostate cancer (mCRPC) is unknown. We hypothesized that patients’ NS at the presentation of mCRPC is prognostic for health-related quality of life (HRQoL) and overall survival (OS). Methods: We conducted a prospective observational study in mCRPC patients. At enrollment, we allocated each patient into one of four NS categories: (i) well-nourished (WN), (ii) nutritional risk without sarcopenia/cachexia (NR), (iii) sarcopenia, or (iv) cachexia. We sought the prognostic role of the NS for OS and HRQoL by regression models. Results: 141 patients were included into our study. When compared to WN patients, those with NR and cachexia had a higher chance of worse HRQoL (OR 3.45; 95% CI [1.28 to 9.09], and OR 4.17; 95% CI [1.28 to 12.5], respectively), as well as shorter OS (HR 2.04; 95% CI [1.19 to 3.39] and HR 2.9; 95% CI [1.56 to 5.41], respectively). However, when accounting for possible confounding factors, we could not prove the significant importance of NS for chosen outcomes. Conclusions: Suboptimal NS might be an unfavorable prognostic factor for HRQoL and OS. Further interventional studies focusing on therapy or prevention are warranted. metastatic castrate-resistant prostate cancer nutritional risk malnutrition outcomes metastatski na kastracijo odporen rak prostate prehransko tveganje podhranjenost true false true Angleški jezik Slovenski jezik Članek v reviji 2024-04-08 15:32:34 2024-04-08 15:32:37 2024-04-09 03:46:02 0000-00-00 00:00:00 2023 0 0 12 str. iss. 4, art. 1044 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 613.2 2072-6643 10.3390/nu15041044 142236931 nutrients-15-01044.pdf nutrients-15-01044.pdf 1 79C73519C40AC14DA6A542C7848DF2E4 514314ac8a2e9cd1802faf8d4fb06eb34757feefb9394c5abd02fad5dfc5996f c31237fa-f5ac-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182604 https://www.mdpi.com/2072-6643/15/4/1044 1 779bb466-f5ac-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182603 Medicinska fakulteta 0 0 0