20.500.12556/RUL-155614 Silica coated Bi$_2$Se$_3$ topological insulator nanoparticles an alternative route to retain their optical properties and make them biocompatible Localized surface plasmon resonance (LSPR) is the cause of the photo-thermal effect observed in topological insulator (TI) bismuth selenide (Bi$_2$Se$_3$) nanoparticles. These plasmonic properties, which are thought to be caused by its particular topological surface state (TSS), make the material interesting for application in the field of medical diagnosis and therapy. However, to be applied, the nanoparticles have to be coated with a protective surface layer, which prevents agglomeration and dissolution in the physiological medium. In this work, we investigated the possibility of using silica as a biocompatible coating for Bi$_2$Se$_3$ nanoparticles, instead of the commonly used ethylene-glycol, which, as is presented in this work, is not biocompatible and alters/masks the optical properties of TI. We successfully prepared Bi$_2$Se$_3$ nanoparticles coated with different silica layer thicknesses. Such nanoparticles, except those with a thick, ≈200 nm silica layer, retained their optical properties. Compared to ethylene-glycol coated nanoparticles, these silica coated nanoparticles displayed an improved photo-thermal conversion, which increased with the increasing thickness of the silica layer. To reach the desired temperatures, a 10–100 times lower concentration of photothermal nanoparticles was needed. In vitro experiments on erythrocytes and HeLa cells showed that, unlike ethylene glycol coated nanoparticles, silica coated nanoparticles are biocompatible. topological insulator bismuth selenide photo-thermal materials biocompatibility nanoparticles true false true Angleški jezik Ni določen Članek v reviji 2024-04-08 13:09:23 2024-04-08 13:09:24 2024-04-09 13:50:43 0000-00-00 00:00:00 2023 0 0 14 str. iss. 5, art. 809 Vol. 13 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 53 2079-4991 10.3390/nano13050809 142713091 nanomaterials-13-00809.pdf nanomaterials-13-00809.pdf 1 FB43CAFEC68A41714E2ED5A38D055C01 7dda1d586b37f4ecd3716704d2bebb31d5a299a430c22066921a0c87bfa182dc cfccff00-f598-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182594 https://www.mdpi.com/2079-4991/13/5/809 1 75af39aa-f598-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182593 Fakulteta za farmacijo 0 0 0