20.500.12556/RUL-155606 Evaluation of monolayer and bilayer buccal films containing metoclopramide The objective of this study was to develop buccal film formulations containing metoclopramide hydrochloride monohydrate (MCP) with and without a backing layer and to evaluate their release properties and physiochemical stability. The crystallization of MCP in the polymer matrix was monitored with image analysis techniques for rapid and scalable observation. The results showed that the addition of a protective layer and its thickness significantly affected the release rate and crystallization behavior of MCP in the formulations. The crystallization of MCP increased over time, and certain formulations showed higher susceptibility to crystallization. To understand the factors affecting the crystallization of MCP, the relationship between the viscosity and pH of the casting solution was examined, but no significant correlation was found. A significant correlation was observed between the plasticizer concentration and the physical state of MCP. Through a systematic Design of Experiment (DOE) approach, an optimal formulation was devised, successfully preventing crystallization of the active ingredient. However, enhancing the overall chemical stability of the formulated product remains a challenge. image analytics Raman microscopy crystallization buccal films bilayer kristalografija slikovna analitika ramanska mikroskopija kristalizacija bukalni filmi dvoslojnost true false true Angleški jezik Slovenski jezik Članek v reviji 2024-04-08 11:23:55 2024-04-08 11:23:58 2024-12-10 15:43:09 0000-00-00 00:00:00 2024 0 0 19 str. iss. 3, art. 354 Vol. 16 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 542:548 1999-4923 10.3390/pharmaceutics16030354 187502595 pharmaceutics-16-00354.pdf pharmaceutics-16-00354.pdf 1 96454D63C2094C179559152F0D7E9924 ee9527a2df3a62b4df774b07c133036e3b1aeebbe91f763e740c7c545a3c4cbb 7e50422f-f58a-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182581 https://www.mdpi.com/1999-4923/16/3/354 1 babc462e-f589-11ee-937a-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182580 Fakulteta za farmacijo 0 0 0