20.500.12556/RUL-155399 The role of isoflavones in the prevention of breast cancer and prostate cancer This narrative review summarizes epidemiological studies on breast cancer and prostate cancer with an overview of their global incidence distribution to investigate the relationship between these diseases and diet. The biological properties, mechanisms of action, and available data supporting the potential role of isoflavones in the prevention of breast cancer and prostate cancer are discussed. Studies evaluating the effects of isoflavones in tissue cultures of normal and malignant breast and prostate cells, as well as the current body of research regarding the effects of isoflavones attained through multiple modifications of cellular molecular signaling pathways and control of oxidative stress, are summarized. Furthermore, this review compiles literature sources reporting on the following: (1) levels of estrogen in breast and prostate tissue; (2) levels of isoflavones in the normal and malignant tissue of these organs in European and Asian populations; (3) average concentrations of isoflavones in the secretion of these organs (milk and semen). Finally, particular emphasis is placed on studies investigating the effect of isoflavones on tissues via estrogen receptors (ER). isoflavones breast cancer prostate cancer medicina bolezni rakava obolenja epidemiološke študije rak dojke rak prostate hrana true false true Angleški jezik Slovenski jezik Članek v reviji 2024-03-29 11:31:23 2024-03-29 11:31:24 2024-03-30 03:50:50 0000-00-00 00:00:00 2023 0 0 27 str. iss. 2, art. 368 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 0000-00-00 616 2076-3921 10.3390/antiox12020368 142086147 antioxidants-12-00368-v2.pdf antioxidants-12-00368-v2.pdf 1 3E11E730047B8D56D5F2CA762643BB88 a3a5241f35a92bf675f5f667db1f0cce983322db3ad5957b8c71c17a82847fbb 213b183e-edb8-11ee-b5ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182265 https://www.mdpi.com/2076-3921/12/2/368 1 7eb67ae7-edb7-11ee-b5ba-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=182264 Zdravstvena fakulteta 0 0 0