20.500.12556/RUL-154597 The effect of polymer–solvent interaction on the swelling of polymer matrix tablets: a magnetic resonance microscopy study complemented by bond fluctuation model simulations Polymer matrix tablets are an important drug-delivery system widely used for oral drug administration. Understanding the tablet hydration process, both experimentally and theoretically, is, thus, very important for the development of drug delivery systems that exhibit high drug loading capacity and controlled release potential. In this study, we used magnetic resonance microscopy (MRM) to nondestructively and dynamically analyze the water hydration process of xanthan-based tablets. The swelling process was characterized by well-resolved fronts of erosion, swelling, and penetration. The experimental results were complemented by numerical simulations of the polymer matrix hydration process. In the simulations, the polymer tablet matrix was modeled as an assembly of interacting chains with embedded drug particles, while its hydration process was mediated by interaction with solvent particles. The swelling dynamics were modeled within a Monte Carlo-based bond fluctuation model (BFM) that elegantly accounted for steric and nearest-neighbor interactions. This study provides an efficient experimental–theoretical approach for the study of polymer matrix swelling processes. drug delivery polymer matrix hydration swelling bond fluctuation model correlation function prenos zdravil true false true Angleški jezik Slovenski jezik Članek v reviji 2024-02-23 07:56:41 2024-02-23 07:56:47 2024-03-28 08:38:49 0000-00-00 00:00:00 2024 0 0 Str. 1-14 iss. 5, [article no.] 601 Vol. 16 Mar. 2024 0000-00-00 Zaloznikova NiDoloceno NiDoloceno 0000-00-00 0000-00-00 2024-03-01 53 2073-4360 10.3390/polym16050601 186456835 polymers-16-00601.pdf polymers-16-00601.pdf 1 8C1B8FFBEEAE57FEDD429FDF4F27180A b4819d20c863b731a7b425e16b3440048d8838f61804f4ba4b72f078d81a8dff 177e7874-d219-11ee-9607-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181111 https://www.mdpi.com/2073-4360/16/5/601 1 b5f8012b-d218-11ee-9607-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181110 Fakulteta za matematiko in fiziko 0 0 0