20.500.12556/RUL-154590 Analiza elektromehanske aktivnosti srca s pomočjo fonoelektrokardiografije pri mačkah s kardiomiopatijami Analysis of cardiac electromechanical activity with the help of phonoelectrocardiography in cats with cardiomyopathies Namen pilotne raziskave je bil preučiti, kako se elektromehanski časovni intervali srca mačk razlikujejo med zdravimi mačkami in mačkami s kardiomiopatijami. V raziskavo smo vključili 29 mačk, od teh je bilo 12 zdravih mačk in 17 mačk s kardiomiopatijo. Poleg kliničnega pregleda in ehokardiografije smo posneli elektrokardiogram (EKG) s simultano fonokardiografijo (PKG). Pri tem smo uporabili pilotno PKG napravo, sestavljeno iz akustičnega stetoskopa, mikrofona in pametnega telefona. Posnetke EKG smo posneli z 12- odvodnim elektrokardiografom, povezanim z osebnim računalnikom. Za sinhronizacijo obeh posnetkov smo sestavili sinhronizacijsko napravo. Naša PKG naprava, sinhronizirana z EKG, se je izkazala za uporabno pri oceni elektromehanske aktivnosti srca mačk. Izmerili smo naslednje električne, elektromehanske ter mehanske intervale: kompleks QRS, interval QT (električna sistola), elektromehanski aktivacijski čas (EMAT oziroma QS1 interval), QS2 interval (električna in mehanska sistola) in interval elektromehanskega okna (EMW). Elektromehanska trajanja smo normalizirali glede na srčni cikel (interval RR) in izračunali korekcijo intervala QT (QTc) s štirimi različnimi formulami. Izmerjena elektromehanska trajanja se med dvema skupinama mačk niso značilno razlikovala, razlikovali pa so se na srčno frekvenco korigirani intervali QRS/RR, QT/RR, EMAT/RR, QS2/RR in S1S2/RR, ki so bili v primerjavi z zdravimi mačkami značilno daljši pri mačkah s kardiomiopatijami. To nakazuje, da potrebuje srce mačk s kardiomiopatijami v primerjavi s srcem zdravih mačk daljši čas za depolarizacijo in repolarizacijo in vzpostavitev primernega tlaka, da se zapre mitralna zaklopka. The aim of our study was to analyse electromechanical time intervals in feline hearts in healthy cats and cats with cardiomyopathy. We included 29 cats, 12 of which were healthy and 17 of which had cardiomyopathy. Cats were examined clinically, echocardiographically, and an electrocardiogram (ECG) with simultaneous phonocardiogram (PCG) was recorded. We used a pilot PCG device built from an acoustic stethoscope, a microphone and a smartphone. We recorded the ECG with a 12-lead ECG device connected to a personal computer. For synchronization purpose of the ECG with the PCG we developed a synchronization device that generates both acoustic and electrical signals with the push of a button. Our pilot PCG device synchronized to ECG proved useful for evaluating the electromechanical activity of the feline heart. We measured electric, electromechanical, and mechanical durations: QRS complex, QT interval (electrical systole), electromechanical activation time (EMAT or QS1 interval), QS2 interval (electrical and mechanical systole), and electromechanical window (EMW) interval. We normalized the electromechanical durations to the cardiac cycle (RR interval) and calculated the corrected QT interval (QTc) with four different formulas. Measured electromechanical durations did not differ significantly between the two groups, however the intervals corrected to heart rate QRS/RR, QT/RR, EMAT/RR, QS2/RR, and S1S2/RR were significantly longer in cats with cardiomyopathies than in healthy cats, suggesting that the heart of cats with cardiomyopathies takes longer in the cardiac cycle to depolarize and repolarize and to generate a pressure high enough to close the mitral valve than the unaffected heart of healthy cats. mačke kardiomiopatije elektrokardiografija fonokardiografija cats cardiomyopathies electrocardiography phonocardiography true false false E. Lunka Slovenski jezik Angleški jezik Raz. nal. na višji ali visoki šoli 2024-02-22 11:14:15 2024-02-22 11:14:15 2024-02-23 03:44:55 0000-00-00 00:00:00 2023 0 Ljubljana 2023 Ljubljana VIII, 57 str. 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 636.09:616.12-008.3:636.8(043.2) 186173699 Lunka_Ema_Presernova_naloga_po_lekturi.pdf Lunka_Ema_Presernova_naloga_po_lekturi.pdf 1 266F5BB1402BE2F30607599C674E635B 0450a9e10857ba4224fc00325c08dfb79de5e835abd36275f64610022ae9a7a0 aaeb201c-d16b-11ee-bea9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181100 http://knjiznica.vf.uni-lj.si/PortalGenerator/Document.aspx?id=423 1 21f8bc95-d16b-11ee-bea9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=181099 Veterinarska fakulteta 0 0 0