20.500.12556/RUL-154321 Pomen določanja troponina I ali/in T pri srčno-žilnih obolenjih The importance of determining troponin I or/and T in cardiovascular diseases Akutni srčni infarkt je resno stanje, pri katerem del srčne mišice ni dovolj oskrbljen s krvjo in se lahko zgodi, da se ta del mišice poškoduje ali odmre. Za diagnozo akutnega srčnega infarkta se uporabljajo različni klinični, elektrokardiografski in biokemični testi, pri čemer je določanje troponina I ali troponina T ena od ključnih biokemičnih analiz. Troponina I in T sta beljakovini, ki se nahajata v srčni mišici. Ko se srčna mišica poškoduje ali odmre, se te beljakovine sprostijo v krvni obtok. Določanje ravni troponina v krvi je pomembno pri diagnosticiranju srčnega infarkta, saj je ta test zelo občutljiv in specifičen za srčno mišico. Z raziskavo smo želeli ugotoviti, kakšen je pomen določanja srčnih troponinov T in I pri različnih oblikah akutnega koronarnega sindroma. Uporabili smo podatke o bolnikih, ki so bili obravnavani na Internistični prvi pomoči Univerzitetnega kliničnega centra v Ljubljani, zaradi bolečine v prsih, in jim je bila izmerjena koncentracija troponina T in I. Ugotovili smo, da obstajajo statistično značilne razlike v koncentracijah troponina T in I pri različnih oblikah akutnega koronarnega sindroma. Najvišje koncentracije tako troponina I kot tudi troponina T so imeli bolniki z diagnozo STEMI. Dokazali smo, da obstaja močna povezanost med troponinom T in I med diagnozami, in da sta največkrat oba povišana pri vseh diagnozah. Dokazali smo tudi, da troponina T in I ne presegata njihovih zgornjih mej. Izračunali smo tudi deleže ujemanja, in ugotovili, da so se v 82 % primerih ravni povišanja troponina T in I ujemale, medtem ko se v 18 % primerih niso ujemale. Za paciente, pri katerih je bil povišan samo en troponin, medtem ko je bil drugi troponin znotraj referenčnih mej, smo pridobili podatek o končni diagnozi oziroma pridruženih boleznih, in pogledali kakšne so koncentracije troponina T oziroma I pri teh diagnozah. An acute myocardial infarction is a serious condition in which part of the heart muscle is not supplied with enough blood, and this part of the muscle may become damaged or die. Various clinical, electrocardiographic and biochemical tests are used for the diagnosis of acute myocardial infarction, with the determination of troponin I or troponin T being one of the key biochemical analyses. Troponins I and T are proteins found in heart muscle. When the heart muscle is damaged or dies, these proteins are released into the bloodstream. Determining the level of troponin in the blood is important in diagnosing a heart attack, as this test is very sensitive and specific for the heart muscle. With the research, we wanted to determine the significance of determining cardiac troponins T and I in various forms of acute coronary syndrome. We used data on patients who were treated at the Emergency Department of the University Medical Center in Ljubljana for chest pain, and their troponin T and I concentrations were measured. We found that there are statistically significant differences in troponin T and I concentrations in different forms of acute coronary syndrome. Patients diagnosed with STEMI had the highest concentrations of both troponin I and troponin T. We have demonstrated that there is a strong correlation between troponin T and I between diagnoses, and that both are most often elevated in all diagnoses. We proved that troponin T and I do not exceed their upper limits. We also calculated concordance ratios and found that in 82 % of cases the levels of troponin T and I elevations matched, while in 18 % of cases they did not match. For patients in whom only one troponin was elevated, while the other troponin was within reference limits, we obtained information on the final diagnosis or associated diseases, and looked at the concentrations of troponin T and I in these diagnoses. troponin akutni koronarni sindrom akutni srčni infarkt troponin acute coronary syndrome acute myocardial infarction. true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2024-02-07 08:45:02 2024-02-07 08:45:07 2024-02-10 03:23:30 0000-00-00 00:00:00 2024 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 104738 20714.pdf 20714.pdf 1 650C1D6130F6BB14173441B1EE17B652 7edc925bd2284e3e32e7803ba2be3c29e29232259c6aa439c3608a7c11bb2b31 d19bbc3f-c58c-11ee-8be4-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180669 Fakulteta za farmacijo 0 0 0