20.500.12556/RUL-154070 Correlating mechanical and rheological filament properties to processability and quality of 3D printed tablets using multiple linear regression Filament formulation for FDM is a challenging and time-consuming process. Several pharmaceutical polymers are not feedable on their own. Due to inadequate filament formulation, 3D printed tablets can also exhibit poor uniformity of tablet attributes. To better understand filament formulation process, 23 filaments were prepared with the polymer mixing approach. To yield processable filaments, brittle and pliable polymers were combined. A 20 % addition of a pliable polymer to a brittle one resulted in filament processability and vice versa. Predictive statistical models for filament processability and uniformity of tablet attributes were established based on the mechanical and rheological properties of filaments. 15 input variables were correlated to 9 responses, which represent filament processability and tablet properties, by using multiple linear regression approach. Filament stiffness, assessed by indentation, and its square term were the only variables that determined the filament’s feedability. However, the resulting model is equipment-specific since different feeding mechanism exert different forces on the filaments. Additional models with good predictive power (R$^2$$ _pred$ > 0.50) were established for tablet width uniformity, drug release uniformity, tablet disintegration time uniformity and occurrence of disintegration, which are equipment-independent outputs. Therefore, the obtained model outcomes could be used in other research endeavours. fused deposition modelling personalized medicine multiple linear regression tablet quality attributes correlation 3D printing modeliranje taljenega nanosa personalizirana medicina večkratna linearna regresija atributi kakovosti tabličnega računalnika korelacija 3D tiskanje farmacevtska tehnologija true false true Angleški jezik Slovenski jezik Članek v reviji 2024-01-23 10:07:28 2024-01-23 10:07:33 2024-04-24 09:55:39 0000-00-00 00:00:00 2024 0 0 14 str. art. 123719 Vol. 651 Feb. 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 661.12:61-027.552 0378-5173 10.1016/j.ijpharm.2023.123719 182047747 1-s2.0-S0378517323011419-main.pdf 1-s2.0-S0378517323011419-main.pdf 1 29BC1EB18D9A4EF50CA6CA35A460D2DB 4f2970dbabb7411cfd50e4d266afce3c896dfcc56221292a3a3962b47105b5fa 7e073299-b9cf-11ee-b1f4-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180227 https://www.sciencedirect.com/science/article/pii/S0378517323011419 1 d88a6fe0-b9ce-11ee-b1f4-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180226 Fakulteta za farmacijo Fakulteta za strojništvo 0 0 0