20.500.12556/RUL-154046 Genetic polymorphisms in oxidative stress and inflammatory pathways as potential biomarkers in Alzheimer’s disease and dementia Oxidative stress and neuroinflammation are important processes involved in Alzheimer’s disease (AD) and mild cognitive impairment (MCI). Numerous risk factors, including genetic background, can affect the complex interplay between those mechanisms in the aging brain and can also affect typical AD hallmarks: amyloid plaques and neurofibrillary tangles. Our aim was to evaluate the association of polymorphisms in oxidative stress- and inflammation-related genes with cerebrospinal fluid (CSF) biomarker levels and cognitive test results. The study included 54 AD patients, 14 MCI patients with pathological CSF biomarker levels, 20 MCI patients with normal CSF biomarker levels and 62 controls. Carriers of two polymorphic IL1B rs16944 alleles had higher CSF Aβ$_{1–42}$ levels (p = 0.025), while carriers of at least one polymorphic NFE2L2 rs35652124 allele had lower CSF Aβ$_{1–42}$ levels (p = 0.040). Association with IL1B rs16944 remained significant in the AD group (p = 0.029). Additionally, MIR146A rs2910164 was associated with Aβ$_{42/40}$ ratio (p = 0.043) in AD. Significant associations with cognitive test scores were observed for CAT rs1001179 (p = 0.022), GSTP1 rs1138272 (p = 0.005), KEAP1 rs1048290 and rs9676881 (both p = 0.019), as well as NFE2L2 rs35652124 (p = 0.030). In the AD group, IL1B rs1071676 (p = 0.004), KEAP1 rs1048290 and rs9676881 (both p = 0.035) remained associated with cognitive scores. Polymorphisms in antioxidative and inflammation genes might be associated with CSF biomarkers and cognitive test scores and could serve as additional biomarkers contributing to early diagnosis of dementia. Alzheimer’s disease oxidative stress inflammation polymorphism biomarker Alzheimerjeva bolezen oksidativni stres vnetje true false true Angleški jezik Slovenski jezik Članek v reviji 2024-01-22 11:33:15 2024-01-22 11:33:20 2024-01-23 03:38:31 0000-00-00 00:00:00 2023 0 0 22 str. iss. 2, art. 316 Vol. 12 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.8 2076-3921 10.3390/antiox12020316 139886083 antioxidants-12-00316-v2.pdf antioxidants-12-00316-v2.pdf 1 27B8B65E7A24F2962EF31EE0A3C35F52 11b95d987107a734effbb2c058168a8d5d110d8a9e10c57892c8b59a2fc438c1 eac4f3af-b911-11ee-88cd-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180190 https://www.mdpi.com/2076-3921/12/2/316 1 aa3e3b3e-b911-11ee-88cd-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180189 Medicinska fakulteta Fakulteta za farmacijo 0 0 0