20.500.12556/RUL-153982 Discovery of compounds with viscosity-reducing effects on biopharmaceutical formulations with monoclonal antibodies For the development of concentrated monoclonal antibody formulations for subcutaneous administration, the main challenge is the high viscosity of the solutions. To compensate for this, viscosity reducing agents are commonly used as excipients. Here, we applied two computational chemistry approaches to discover new viscosity-reducing agents: fingerprint similarity searching, and physicochemical property filtering. In total, 94 compounds were selected and experimentally evaluated on two model monoclonal antibodies, which led to the discovery of 44 new viscosity-reducing agents. Analysis of the results showed that using a simple filter that selects only compounds with three or more charge groups is a good ‘rule of thumb’ for selecting potential viscosity-reducing agents for two model monoclonal antibody formulations. viscosity protein formulations biopharmaceuticals viscosity-reducing agents computational screening viskoznost proteinske formulacije biofarmacevtski izdelki sredstva za zmanjševanje viskoznosti računalniško preverjanje true false true Angleški jezik Slovenski jezik Članek v reviji 2024-01-17 15:51:41 2024-01-17 15:51:44 2024-01-18 03:42:11 0000-00-00 00:00:00 2022 0 0 Str. 5420-5429 Vol. 20 2022 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 532.13+541.8 2001-0370 10.1016/j.csbj.2022.09.035 123845891 1-s2.0-S2001037022004408-main.pdf 1-s2.0-S2001037022004408-main.pdf 1 B570CCDA600F91C62503E612953688CA 98ee240b36db21db8d6e75464db545aaae9e7350c442bd4a947d6c60254af485 b8568ce0-b548-11ee-b3d9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180084 https://www.sciencedirect.com/science/article/pii/S2001037022004408 0 ef1909d3-b547-11ee-b3d9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=180083 Fakulteta za farmacijo 0 0 0