20.500.12556/RUL-153377 Kognitivne in emocionalne posledice multisistemskega vnetnega sindroma pri otrocih (MIS-C) magistrsko delo Cognitive and emotional sequelae of multisystem inflammatory syndrome in children (MIS-C) Večsistemski vnetni sindrom pri otrocih (MIS-C) se razvije v postinfekcijski fazi okužbe s SARS-CoV-2 virusom in prizadene številne organske sisteme, vključno z živčnim sistemom. Čeprav si večina otrok in mladostnikov z MIS-C telesno dobro opomore, pri precejšnjem deležu vztrajajo kognitivne in čustvene posledice. Ker je spoznavni upad pri posameznikih z anksioznimi in depresivnimi motnjami dobro raziskan v pretekli literaturi, je namen magistrske raziskave ugotoviti, ali se anksioznost in depresivnost pri pacientih z MIS-C povezujeta s primanjkljaji v besednem in vidnem spominu, kratkoročnem vidno-prostorskem spominu, hitrosti procesiranja informacij ter izvršilnih funkcijah. Hipoteze so bile preverjene s sekundarno analizo podatkov, zbranih v sklopu Registra otrok s sistemskimi imunsko posredovanimi boleznimi. Končni vzorec je sestavljalo 47 pacientov z MIS-C, ki so bili testirani z RAVLT, RCFT, CCTT, ToLDX ter računalniško verzijo testa Corsi kock. Njihovi starši so izpolnili vprašalnik CBCL. Anksioznost in depresivnost se pri udeležencih v splošnem nista povezovali s kognitivnimi primanjkljaji. Pokazala se je pozitivna povezava med anksioznostjo in rezultati na CCTT 1. Ob kontroliranju za anksiozne simptome je bila ugotovljena zmerna negativna povezava med depresivnostjo in izvršilnimi funkcijami. Kognitivni primanjkljaji po MIS-C najverjetneje ne nastanejo zaradi povišane anksioznosti in depresivnosti, temveč zaradi drugih mehanizmov. Zaradi majhnega števila udeležencev z mejno ali klinično povišanimi simptomi anksioznosti in depresivnosti ugotovitev raziskave ne moremo posploševati na splošno populacijo otrok in mladostnikov z MIS-C. Multisystem inflammatory syndrome in children (MIS-C) develops in the post-infectious phase of SARS-CoV-2 infection and impacts several organ systems, including the nervous system. Even though most children and adolescents with MIS-C recover well physically, some experience persistent cognitive and emotional sequelae. Since a cognitive decline in individuals with anxious and depressive disorders is well documented in previous literature, my master's thesis aims to explore whether anxiety and depression are associated with deficits in verbal and visual memory, short-term visuospatial memory, information processing speed, and executive functions. Hypotheses were tested using secondary analysis of data, collected by the Registry of Children with Systemic Immune-mediated Diseases. The final sample consisted of 47 patients with MIS-C who were tested with RAVLT, RCFT, CCTT, ToLDX, and a computerized version of the Corsi block tapping test. Their parents filled out the CBCL questionnaire. Anxiety and depression in participants were generally not related to cognitive deficits. A significant positive relationship emerged between anxiety and CCTT 1. When controlling for anxious symptoms, a moderate negative relationship was found between depression and executive functions. Cognitive deficits after MIS-C most likely do not arise due to heightened anxiety and depression but because of other mechanisms. The results of this study cannot be extrapolated to the general population of children and adolescents with MIS-C due to the small number of participants with borderline or clinical anxiety and depression. post covid-19 stanja imunološke motnje kognitivni primanjkljaji anksioznost depresivnost post-COVID-19 conditions immunologic disorders cognitive impairment anxiety depression true false false [Ž. Krajnc] Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-12-24 07:46:04 2023-12-24 07:46:17 2024-01-23 12:24:26 0000-00-00 00:00:00 2023 0 Ljubljana 0 Ljubljana 71 str. 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 159.97:616-053.2(043.2) 542200 182124035 37226.pdf 37226.pdf 1 8EA3314B07BC600CA9F02BFF83365D5C dd6591ce6bf4cf63c40f121ff6fe0caa051e10d0f623dab382d41c439bc257c1 22c73877-a228-11ee-8489-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=179313 Filozofska fakulteta 0 0 0