20.500.12556/RUL-152834 Nicotinic acetylcholine receptors in cancer limitations and prospects Nicotinic acetylcholine receptors (nAChRs) have long been considered to solely mediate neurotransmission. However, their widespread distribution in the human body suggests a more diverse physiological role. Additionally, the expression of nAChRs is increased in certain cancers, such as lung cancer, and has been associated with cell proliferation, epithelial-to-mesenchymal cell transition, angiogenesis and apoptosis prevention. Several compounds that interact with these receptors have been identified as potential therapeutic agents. They have been tested as drugs for treating nicotine addiction, alcoholism, depression, pain and Alzheimer's disease. This review focuses on nAChR-mediated signalling in cancer, presenting opportunities for the development of innovative nAChR-based anticancer drugs. It displays the differences in expression of each nAChR subunit between normal and cancer cells for selected cancer types, highlighting their possible involvement in specific cases. Antagonists of nAChRs that could complement existing cancer therapies are summarised and critically discussed. We hope that this review will stimulate further research on the role of nAChRs in cancer potentially leading to innovative cancer therapies. nAChR cancer signalling antagonist apoptosis angiogenesis mitochondria therapy true false true Angleški jezik Ni določen Članek v reviji 2023-12-08 12:09:37 2023-12-08 12:09:37 2023-12-09 03:49:41 0000-00-00 00:00:00 2024 0 0 18 str. iss. 1, art. 166875 Vol. 1870 2024 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.2 0925-4439 10.1016/j.bbadis.2023.166875 164011779 1-s2.0-S0925443923002417-main.pdf 1-s2.0-S0925443923002417-main.pdf 1 8F0B4290B31208E76FFC026222F5B67F 5d1aca6ee664b44cf7cb96c4cd6d15feb7018ea3b9f12f2b6b116ac827498dd2 a1a1dce7-95ba-11ee-9c20-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178519 https://www.sciencedirect.com/science/article/pii/S0925443923002417 0 748db8b4-95ba-11ee-9c20-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178518 Medicinska fakulteta Biotehniška fakulteta 0 0 0