20.500.12556/RUL-152686 Gold-assisted molecular imaging of organic tissue by MeV secondary ion mass spectrometry The quality of molecular imaging by means of MeV primary ion-induced secondary ion mass spectrometry by coating with gold was evaluated on different reference organic molecules and plant samples. The enhancement of the secondary ion yield was evident for the majority of the studied analytes, reaching the highest values at gold thicknesses between 0.5 and 2 nm, and increased the intensity up to 5-fold for reference samples and >2-fold for specific peaks within the plant sample. Improved propagation of the electric field due to the target potential on otherwise electrically insulating plant samples was also evident through improved image resolution and by reducing the background in mass spectra. However, detection of several molecules was significantly decreased at even at 1 nm thick gold layer. The results indicated that an optimized sequence of analysis is required to reliably interpret results. molecular imaging organic tissue secondary ion mass spectrometry coating materials gold grain ions thickness molekularno slikanje tkivo masna spektrometrija sekundarnih ionov true false true Angleški jezik Slovenski jezik Članek v reviji 2023-12-04 13:45:32 2023-12-04 13:45:36 2023-12-05 03:41:07 0000-00-00 00:00:00 2023 0 0 Str. 2358-2364 iss. 10 Vol. 34 Oct. 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 543.2/.9 1879-1123 10.1021/jasms.3c00237 164066819 jencic-et-al-2023-gold-assisted-molecular-imaging-of-organic-tissue-by-mev-secondary-ion-mass-spectrometry.pdf jencic-et-al-2023-gold-assisted-molecular-imaging-of-organic-tissue-by-mev-secondary-ion-mass-spectrometry.pdf 1 4DEF66BDABAFE465E327973960218333 6f9503bd070f38a294cdd348a170f79e14fafe010716ead5b944cffc7cd14fe7 4909e301-92a3-11ee-9ca9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178296 https://pubs.acs.org/doi/10.1021/jasms.3c00237 1 060320aa-92a3-11ee-9ca9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178295 Biotehniška fakulteta 0 0 0