20.500.12556/RUL-152630 Objective monitoring of laser tattoo removal in human volunteers using an innovative optical technique a proof of principle Objectives: Assess the suitability of the technique for objective monitoring of laser tattoo removal by an extended treatment protocol. Materials and Methods: One half of the tattoo in the first volunteer was treated with nanosecond and the other half with picosecond laser pulses at 1064 nm. In the second subject, four test areas were treated repeatedly using different radiant exposures from 1.5 to 6 J/cm$^2$. Measurements of diffuse reflectance spectra and photothermal radiometric transients were performed 4–20 weeks after each treatment session. Inverse Monte Carlo analysis based on a three‐layer model of tattooed skin was applied to assess the tattoo characteristics and analyze their changes. Results: The results clearly indicate a gradual reduction of the ink content and an increase of the subsurface depth of the tattoo layer with all treatments at a radiant exposure of 3 J/cm$^2$ or higher. The observed dependences on laser pulse duration, radiant exposure, and a number of treatments are in excellent agreement with visual fading of the tattoo. Conclusions: The presented methodology enables noninvasive characterization of tattoos in human skin and objective monitoring of the laser removal treatment. diffuse reflectance spectroscopy inverse Monte Carlo laser tattoo removal pulsed photothermal radiometry skin characterization true false true Angleški jezik Ni določen Članek v reviji 2023-12-01 10:26:28 2023-12-01 10:26:30 2023-12-02 03:49:23 0000-00-00 00:00:00 2023 0 0 Str. 724-733 iss. 8 Vol. 55 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 535 1096-9101 10.1002/lsm.23720 163247107 Lasers_Surg_Med_-_2023_-_Golmajer_Zima_-_Objective_monitoring_of_laser_tattoo_removal_in_human_volunteers_using_an.pdf Lasers_Surg_Med_-_2023_-_Golmajer_Zima_-_Objective_monitoring_of_laser_tattoo_removal_in_human_volunteers_using_an.pdf 1 F3D0B536AE309E224C6AD3F16C97F032 79d79d35a62f33b93eae6cc5486a651d96e783de5578a2a29c4fb2590b9587ae fe0f7d54-902b-11ee-b3b7-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178213 https://onlinelibrary.wiley.com/doi/10.1002/lsm.23720 0 d9b404ac-902b-11ee-b3b7-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178212 Fakulteta za matematiko in fiziko Fakulteta za šport 0 0 0