20.500.12556/RUL-152576 Absence of post-treatment changes in sentinel lymph nodes does not translate into increased regional recurrence rate in initially node-positive breast cancer patients Purpose To determine whether the absence of post-treatment changes in the negative sentinel lymph nodes (SLN) in the neoadjuvant setting for biopsy-proven cN + disease results in an increased regional recurrence (RR) rate in patients after SLN biopsy (SLNB) only. Methods Breast cancer patients with biopsy-proven cN + disease who converted to node-negative disease after neoadjuvant systemic treatment (NAST) and underwent SLNB only were included. Retrospective analysis was performed for patients diagnosed between 2008 and 2021. Pathohistological specimens were reviewed for the presence of post-treatment changes in the SLNs. Patients with negative SLNs (ypN0) were divided into two groups: (i) with post-treatment changes, (ii) without post-treatment changes. Patients' characteristics were compared between groups. Crude RR rates were compared using the log-rank test. Recurrence-free (RFS) and overall survival (OS) for the entire cohort were calculated using Kaplan–Meier. Results Of 437 patients with cN + disease, 95 underwent SLNB only. 82 were ypN0, 57 with post-treatment changes (group 1), 25 without post-treatment changes (group 2). During the median follow-up of 37 months (range 6–148), 1 isolated regional recurrence occurred in group 2 (RR rate 0% for group 1 vs. 4% for group 2, p = 0.149). There were no differences in 3-year RFS and OS between groups. Conclusion Absent post-treatment changes in negative SLNs for biopsy-proven cN + disease that covert to node-negative after NAST did not result in increased regional recurrence rates in our cohort. Multidisciplinary input is essential to determine whether additional treatment is needed in these patients. breast cancer neoadjuvant post-treatment changes sentinel lymph node biopsy regional recurrence rak dojke neoadjuvantno zdravljenje posledice zdravljenja true false true Angleški jezik Slovenski jezik Članek v reviji 2023-11-29 10:48:19 2023-11-29 10:48:23 2023-11-30 03:42:11 0000-00-00 00:00:00 2023 0 0 Str. 443–450 iss. 3 Vol. 202 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 0167-6806 10.1007/s10549-023-07084-x 164764163 s10549-023-07084-x_(1).pdf s10549-023-07084-x_(1).pdf 1 0217E48FF38238C03AE4FD3D4009EE4A 3dbdce4715f5792390432e51f50e2b6362e10e11e12157885da50a62e7e176cf b29c16d2-8e9c-11ee-9c6c-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178123 https://link.springer.com/article/10.1007/s10549-023-07084-x 0 9544c313-8e9c-11ee-9c6c-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178122 Medicinska fakulteta 0 0 0