20.500.12556/RUL-152542 Clinical and laboratory predictors for prosthetic joint infection within the first postoperative days following primary total hip and knee arthroplasty Purpose To identify clinical and laboratory predictors for low- and high-grade prosthetic joint infection (PJI) within the first postoperative days following primary total hip/knee arthroplasty (THA/TKA). Methods Institutional bone and joint infection registry of a single osteoarticular infection referral centre was reviewed to identify all osteoarticular infections treated between 2011 and 2021. Among them were 152 consecutive PJI (63 acute high-grade PJI, 57 chronic high-grade PJI, and 32 low-grade PJI) who also had primary THA/TKA performed at the same institution, which were retrospectively analyzed with multivariate logistic regression and covariables. Results For each additional day of wound discharge, persistent wound drainage (PWD) predicted PJI in the acute high-grade PJI group with odds ratio (OR) 39.4 (p = 0.000, 95%CI 1.171–1.661), in the low-grade PJI group with OR 26.0 (p = 0.045, 95%CI 1.005–1.579), but not in the chronic high-grade PJI group (OR 16.6, p = 0.142, 95%CI 0.950–1.432). The leukocyte count product of pre-surgery and POD2 >100 predicted PJI in the acute high-grade PJI group (OR 2.1, p = 0.025, 95%CI 1.003–1.039) and in the chronic high-grade PJI group (OR 2.0, p = 0.018, 95%CI 1.003–1.036). Similar trend was also seen in the low-grade PJI group, but was not statistically significant (OR 2.3, p = 0.061, 95%CI 0.999–1.048). Conclusions The most optimal threshold value for predicting PJI was observed only in the acute high-grade PJI group, where PWD >three days after index surgery yielded 62.9% sensitivity and 90.6% specificity, whereby the leukocyte count product of pre-surgery and POD2 >100 showed 96.9% specificity. Glucose, erythrocytes, hemoglobin, thrombocytes, and CRP showed no significant value in this regard. prosthetic joint infection PJI predictor total hip arthroplasty total knee arthroplasty true false true Angleški jezik Ni določen Članek v reviji 2023-11-27 10:43:44 2023-11-27 10:43:45 2024-09-30 10:56:54 0000-00-00 00:00:00 2023 0 0 Str. 2173–2179 iss. 9 Vol. 47 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 617.3 1432-5195 10.1007/s00264-023-05891-x 160824579 RAZ_Brumat_Peter_2023.pdf RAZ_Brumat_Peter_2023.pdf 1 FB1FC71BFA19759DF12217409D549D04 60b896c7883dbf4ffb1a853496ea942b93191d8c43194f34a537ca2ea5e85eec 765e231f-8d09-11ee-8ac8-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178067 https://link.springer.com/article/10.1007/s00264-023-05891-x 0 95b6c1f2-8d09-11ee-8ac8-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=178068 Medicinska fakulteta 0 0 0