20.500.12556/RUL-152331 Evaluating cancer screening programs using survival analysis The main purpose of cancer screening programs is to provide early treatment to patients that are diagnosed with cancer on a screening test, thus increasing their chances of survival. To test this hypothesis directly, one should compare the survival of screen-detected cases to the survival of their counterparts not included to the program. In this study, we develop a general notation and use it to formally define the comparison of interest. We explain why the naive comparison between screen-detected and interval cases is biased and show that the total bias that arises in this case can be decomposed as a sum of lead time bias, length time bias, and bias due to overdetection. With respect to the estimation, we show what can be estimated using existing methods. To fill in the missing gap, we develop a new nonparametric estimator that allows us to estimate the survival of the control group, that is, the survival of cancer cases that would be screen-detected among those not included to the program. By joining the proposed estimator with existing methods, we show that the contrast of interest can be estimated without neglecting any of the biases. Our approach is illustrated using simulations and empirical data. bias breast cancer survival analysis cancer screening counterfacts rak na dojki statistika analiza preživetja true false true Angleški jezik Slovenski jezik Članek v reviji 2023-11-20 10:56:34 2023-11-20 10:56:37 2023-11-21 03:36:49 0000-00-00 00:00:00 2023 0 0 24 str. iss. 7, art. 2200344 Vol. 65 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616-006 0323-3847 10.1002/bimj.202200344 154649603 Biometrical_J_-_2023_-_Vratanar_-_Evaluating_cancer_screening_programs_using_survival_analysis.pdf Biometrical_J_-_2023_-_Vratanar_-_Evaluating_cancer_screening_programs_using_survival_analysis.pdf 1 CF8704DFD5164C30290A78B80F95559D dfffcd9e509c11d3a99851fa8160e3019c56514a1e12a2276ac14043a34f76ed 84d4e50c-878b-11ee-9dd9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=177774 https://onlinelibrary.wiley.com/doi/10.1002/bimj.202200344 0 45ce53c7-878b-11ee-9dd9-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=177773 Medicinska fakulteta 0 0 0