20.500.12556/RUL-151579 Influence of fused deposition modelling printing parameters on tablet disintegration times a design of experiments study Despite the importance of process parameters in the printing of solid dosage forms using fused deposition modelling (FDM) technology, the field is still poorly explored. A design of experiment study was conducted to understand the complete set of process parameters of a custom developed FDM 3D printer and their influence on tablet disintegration time. Nine settings in the Simplify 3D printing process design software were evaluated with further experimental investigation conducted on the influence of infill percentage, infill pattern, nozzle diameter, and layer height. The percentage of infill was identified as the most impactful parameter, as increasing it parabolically affected the increase of disintegration time. Furthermore, a larger nozzle diameter prolonged tablet disintegration, since thicker extruded strands are generated through wider nozzles during the printing process. Three infill patterns were selected for in-depth analysis, demonstrating the clear importance of the geometry of the internal structure to resist mechanical stress during the disintegration test. Lastly, layer height did not influence the disintegration time. A statistical model with accurate fit ($R^2$ = 0.928) and predictability ($Q^2$ = 0.847) was created. In addition, only the infill pattern and layer height influenced both the uniformity of mass and uniformity of the disintegration time, which demonstrates the robustness of the printing process. 3D printed tablets disintegration time fused depo-sition modelling design of experiments printing parameters uniformity of mass 3D tiskane tablete razpadni čas modeliranje taljenega nanosa zasnova eksperimentov parametri tiskanja enakomernost mase true false true Angleški jezik Slovenski jezik Članek v reviji 2023-10-10 10:14:51 2023-10-10 10:14:54 2023-10-11 03:33:51 0000-00-00 00:00:00 2023 0 0 Str. 405-422 no. 3 Vol. 73 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 615.45 1330-0075 10.2478/acph-2023-0026 167452419 10.2478_acph-2023-0026.pdf 10.2478_acph-2023-0026.pdf 1 1455F25A350D86417D146EFDC6C2AE3C 6d6f2c29609fcd69c978ed97b3ac36fd53575acecca8c2d74c67e97aceeec74d 1e1a0392-6746-11ee-9430-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=176573 https://sciendo.com/article/10.2478/acph-2023-0026 1 18f62f13-6745-11ee-9430-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=176572 Fakulteta za farmacijo 0 0 0