20.500.12556/RUL-151010 Razvoj in validacija analizne metode za določanje bioloških označevalcev ftalatov in njihovih zamenjav v materinem mleku Development and validation of the analytical method for determination of biomarkers of phthalates and their replacements in human breast milk Ftalati se uporabljajo kot mehčala za plastiko in jih tako dandanes srečamo v številnih izdelkih. Pojavljajo se v kozmetiki, farmacevtskih oblogah, tekstilu, embalaži za hrano in tudi v živilih, kamor pridejo preko odpuščanja iz embalaže, ker niso kemijsko vezani na plastične polimere. V veliki meri smo jim izpostavljeni že od rojstva in imajo dokazane negativne učinke na zdravje, zato se je v preteklih letih povečalo raziskovanje izpostavljenosti in njihovih škodljivih učinkov. To se izvaja v obliki študij humanega biomonitoringa na različnih vzorcih, največkrat sta to urin ali kri. Vendar pa je pridobitev slednje preveč invazivna za najmlajšo populacijo; dojenčke. Ker so dojeni dojenčki ftalatom in drugim kemijskim motilcem endokrinega sistema lahko potencialno izpostavljeni preko njihovega glavnega vira hrane, materinega mleka, smo želeli ugotoviti, katerim metabolitom ftalatov in njihovim zamenjavam so izpostavljeni ter v kolikšni meri. Phthalates are nowadays in numerous products as they are used as plasticizers. They can also be found in cosmetics, pharmaceutical coatings, textiles, food contact materials and even in food as they leach from the containers since they are not chemically bound to plastic materials. Humans are widely exposed to them since birth therefore in the past couple of years there has been an increase in research of exposure and their harmful effects. These are so-called human biomonitoring studies which include different matrixes, most commonly used are urine and blood. Since blood sampling is too invasive for the youngest population, babies. That is why we have decided for determining phthalate metabolites and their replacement biomarkers in human breast milk since this is main source of the babies’ exposure. ftalati materino mleko validacija LC-MS/MS humani biomonitoring phthalates human breast milk validation LC-MS/MS human biomonitoring true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-09-27 08:45:02 2023-09-27 08:45:07 2023-09-28 03:43:14 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 101675 18057.pdf 18057.pdf 1 892937B961175663463641B7DC9B233D d83976cc786ce67c9f57d39503e832bc600b5466bef4c3a01ecbb3d8102f43fe 6931c04e-5d01-11ee-a9d7-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=175892 Fakulteta za farmacijo 0 0 0