20.500.12556/RUL-149870 Pathological and therapeutic significance of tumor-derived extracellular vesicles in cancer cell migration and metastasis The infiltration of primary tumors and metastasis formation at distant sites strongly impact the prognosis and the quality of life of cancer patients. Current therapies including surgery, radiotherapy, and chemotherapy are limited in targeting the complex cell migration mechanisms responsible for cancer cell invasiveness and metastasis. A better understanding of these mechanisms and the development of new therapies are urgently needed. Extracellular vesicles (EVs) are lipid enveloped particles involved in inter-tissue and inter-cell communication. This review article focuses on the impact of EVs released by tumor cells, specifically on cancer cell migration and metastasis. We first introduce cell migration processes and EV subtypes, and we give an overview of how tumor derived EVs (TDEVs) may impact cancer cell migration. Then, we discuss ongoing EV-based cancer therapeutic approaches, including the inhibition of general EV-related mechanisms as well as the use of EVs for anti-cancer drug delivery, focusing on the harnessing of TDEVs. We propose a protein-EV shuttle as a route alternative to secretion or cell membrane binding, influencing downstream signaling and the final effect on target cells, with strong implications in tumorigenesis. Finally, we highlight the pitfalls and limitations of therapeutic EV exploitation that must be overcome to realize the promise of EVs for cancer therapy. extracellular vesicles tumor-derived extracellular vesicles cancer cell migration epithelial-mesenchymal transition tumor metastasis cancer therapy alternative signaling routes drug delivery extracellular vesicle exploitation quality control true false true Angleški jezik Ni določen Članek v reviji 2023-09-11 10:46:44 2023-09-11 10:46:45 2023-12-05 13:02:28 0000-00-00 00:00:00 2023 0 0 23 str. iss.18, art. 4425 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno apc 0000-00-00 0000-00-00 2023-09-05 577:616-006 2072-6694 10.3390/cancers15184425 163943939 cancers-15-04425.pdf cancers-15-04425.pdf 1 4282A9CA9FD2CAD82F20F2F4C942677F 0e3b9db4e3e2b11cffc8d9d8f8825d49aec74ad27d9fcfe239623c09a5361f64 1f25e36c-5080-11ee-9bb0-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=174376 https://www.mdpi.com/2072-6694/15/18/4425 1 bd7c1b6b-507f-11ee-9bb0-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=174375 Zdravstvena fakulteta 0 0 0