20.500.12556/RUL-149791 Primerjava nukleotidnih zaporedij promotorjev TLR10 pri različnih vrstah sesalcev Comparison of TLR10 promoter in different mammalian species Toll-u podobni receptorji (angl. »Toll-like receptors«, TLR) so najbolj raziskani receptorji iz skupine receptorjev, ki prepoznavajo molekulske vzorce (angl. »pattern-recognition receptors«, PRR). V skupino TLR spada tudi TLR10, ki je pomemben za prepoznavanje patogenov in regulacijo aktivacije imunskega odziva. V diplomskem delu smo izvedli primerjavo zaporedij DNA TLR10 različnih vrst sesalcev in primerjavo nukleotidnega zaporedja osnovnih promotorjev humanih TLR1, TLR2, TLR6 in TLR10. Naredili smo tudi primerjavo zaporedij osnovnega promotorja humanega TLR10 pri različnih vrstah sesalcev. Na koncu smo poiskali vezavna mesta za transkripcijske dejavnike in primerjali ohranjenost le-teh v osnovnem promotorju TLR10 pri različnih vrstah sesalcev. Dobljeni rezultati kažejo na visoko stopnjo ohranjenosti zaporedja TLR10 v promotorskih regijah in vezavnih mestih transkripcijskih dejavnikov pri različnih vrstah sesalcev. Toll-like receptors (TLRs) are the most studied receptors in the group of molecular pattern-recognition receptors (PRRs). TLRs include TLR10, that is important for recognition of pathogens and regulation of the immune response activation. In my thesis we compared the DNA sequences of TLR10 from different mammalian species and compared the nucleotide sequences of the core promoters of human TLR1, TLR2, TLR6 and TLR10. We also compared the core promoter sequences of human TLR10 with those of different mammalian species. Finally, we searched for transcription factor binding sites and compared their conservation in the TLR10 core promoter in different mammalian species. The results show a high degree of sequence conservation in the promoter regions and binding sites of human TLR10 transcription factors in different mammalian species. PRR TLR10 TLR1 TLR2 TLR6 različne vrste sesalcev promotor nukleotidno zaporedje transkripcijski dejavniki PRR TLR10 TLR1 TLR2 TLR6 different mammalian species promoter nucleotide sequence transcription factors true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2023-09-10 07:17:11 2023-09-10 07:17:12 2023-10-05 11:44:59 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 228946 164361475 35201.pdf 35201.pdf 1 EDD1030C321602BB47629820621B6075 99b8d2542bb575137ce4bdbeeeb9a4e9db42044ba2c5dc46bd5af9ad8ff2396c 4c90fadc-4f99-11ee-a2ce-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=174295 Biotehniška fakulteta 0 0 0