20.500.12556/RUL-149479 Sinteza in pretvorbe 6-substituiranih-4,5-dihidropiridazin-3(2H)-onov Synthesis and transformation of 6-substituated-4,5-dihydropyridazin-3(2H)-ones V sklopu diplomskega dela smo iz ustreznih γ-keto kislin 1a in 1b ter hidrazin hidrata uspešno sintetizirali 6-substituirana-4,5-dihidropiridazin-3(2H)-ona 2a in 2b, pri čemer a označuje fenil, b pa metil substituiran analog. Spojino 2a smo nato poskušali reducirati do 6-feniltetrahidropiridazin-3(2H)-ona (3a) z različnimi reducenti. Ta pretvorba je bila le delno uspešna zaradi težave pri izolaciji. Spojino 3a pa je možno naprej uporabiti za tvorbo N,N-cikličnih azometin iminov preko 1,3-dipolarne cikloadicije. Spojini 2a in 2b smo uspešno oksidirali do ustreznih 6-substituiranih piridazin-3(2H)-onov 5a in 5b. Ti dve spojini sta potencialna reagenta v nadaljnjih fotokemijskih pretvorbah. As a part of this Bachelor’s thesis the 6-substituated-4,5-dihydropyridazin-3(2H)-ones 2a and 2b were synthetized using the corresponding γ-keto acids 1a and 1b and hydrazine hydrate (a = Ph, b = Me). Compound 2a was then reduced to 6-phenyltetrahydropyridazin-3(2H)-one (3a). Many different reducing agents were tested but only few of them yielded the desired compound 3a, which was obtained in low yield because of the problems with isolation. Compound 3a can be used in the synthesis of N,N-cyclic azomethine imines via 1,3-dipolar cycloaddition. Compounds 2a and 2b were successfully oxidised to 6-substituated pyridazin-3(2H)-ones 5a and 5b, which are potential reagents in photochemical reactions. piridazinoni redukcija oksidacija pyridazinones reduction oxidation true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2023-09-07 11:00:00 2023-09-07 11:00:01 2023-10-19 12:29:50 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 22881 169113603 Frelih_Blaz_-_Sinteza_in_pretvorbe_6-substituiranih-4,5-dihidropiridazin-3(2H)-onov.pdf Frelih_Blaz_-_Sinteza_in_pretvorbe_6-substituiranih-4,5-dihidropiridazin-3(2H)-onov.pdf 1 5976A4836E9148F879A3EB0B8236FCD4 463f77adde1dcc27a146604cd0180d82a8c1ba4bd8e017964c53f55acb4d95e6 ee4010ea-4d5c-11ee-9934-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=173960 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0