20.500.12556/RUL-149229 Priprava izbranih 2-naftilaminov z Buchererjevo reakcijo Preparation of selected 2-naphthylamines by Bucherer reaction V diplomskem delu je predstavljena sinteza treh 2-naftilaminskih produktov. Sintezo smo izvajali v dveh stopnjah. V prvi smo uspešno pripravili ketonski derivat iz 6-bromo-2-naftola in 2-hidroksietil vinil etra s Heckovo reakcijo. Pri reakciji je kot katalizator nastopal in situ tvorjen paladijev(0) kompleks. V drugi stopnji smo hidroksilno skupino 1-(6-hidroksinaftalen-2-il)etan-1-ona zamenjali z izbranim sekundarnim aminom (dimetilaminom, piperidinom ali pirolidinom). Reakcija, ki smo jo izvajali v avtoklavu, je potekala po mehanizmu Buchererjeve reakcije. Sinteze vseh treh produktov so bile uspešno izvedene, produkti pa ustrezno okarakterizirani. This bachelor's thesis presents the synthesis of three distinct 2-naphthylamines through a two-stage approach. The first stage encompassed the preparation of a ketone from 6-bromo-2-naphthol and 2-hydroxyethyl vinyl ether via Heck reaction. The palladium(0) complex was formed in situ and acted as the catalyst. In the second stage, the hydroxil group of 1-(6-hydroxynaphthalen-2-yl)ethan-1-on was substituted with a selected secondary amine (dimethylamine, piperidine or pyrrolidine) via Bucherer reaction. The reaction was performed in an autoclave. All three syntheses were carried out successfully. Buchererjeva reakcija Heckova reakcija 2-naftilamini paladijev katalizator Bucherer reaction Heck raction 2-naphthylamines palladium catalyst true false false Slovenski jezik Angleški jezik Diplomsko delo/naloga 2023-09-05 12:20:00 2023-09-05 12:20:02 2023-10-09 14:41:20 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 22898 167193603 Rupnik_Nika_-_Priprava_izbranih_2-naftilaminov_z_Buchererjevo_reakcijo.pdf Rupnik_Nika_-_Priprava_izbranih_2-naftilaminov_z_Buchererjevo_reakcijo.pdf 1 DA745B684A2C7DA286C880884512C394 e19b19e54b2ffb91adece49472880b1285b0abab6d56360e33b5c41ec9b4058b c4113039-4bd5-11ee-af86-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=173654 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0