20.500.12556/RUL-148656 Development of simvastatin-loaded particles using spray drying method for ex tempore preparation of cartridges for 2D printing technology In this work, a spray drying method was developed to produce drug/polymer (simvastatin/polycaprolactone) microparticles that have the potential to be used as a pre-formulation for ex tempore preparation of 2D printing cartridges. An experimental model was designed with the process parameters set to predict the smallest particle size required for successful 2D printing. Three different types of particles (lactose, nanocellulose/lactose, calcium silicate) were produced, and the average size of the dry particles varied depending on the sampling location (cyclone, collection vessel). The encapsulation efficiency of simvastatin was highest with nanocellulose/lactose from the collection vessel. The one-month stability of simvastatin in the particles showed low content, but the addition of ascorbic acid as an antioxidant increased the chemical stability of the drug. Interestingly, the addition of antioxidants decreased the stability of simvastatin in the calcium silicate particles from the collection vessel. Dispersion of the particles in three different propylene glycol and water mixtures (10/90, 50/50, and 90/10% (v/v)), representing a printable ink medium with three different viscosity and surface tension properties, showed that nanocellulose/lactose was the most suitable antiadhesive in terms of dispersed particle size (˂1 µm). After one month of storage, the dispersed particles remained in the same size range without undesirable particle agglomeration. inkjet printing spray drying design of experiments simvastatin antioxidants stability ink medium nanocellulose particle size emulsion brizgalno tiskanje sušenje z razprševanjem načrtovanje poskusov simvastatin antioksidanti stabilnost medij črnila nanoceluloza velikost delca emulzije sušenje farmacevtska tehnologija true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-29 08:14:57 2023-08-29 08:15:02 2024-12-10 14:56:20 0000-00-00 00:00:00 2023 0 0 22 str. iss. 9, art. 2221 Vol. 15 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 542.9:542.7 1999-4923 10.3390/pharmaceutics15092221 162436099 pharmaceutics-15-02221.pdf pharmaceutics-15-02221.pdf 1 EB1CA4541B13F3D57C094B76C0001E61 9aa43af23c706d24f1d377dc842d8dcac8ce44e7c735cb671868a977f7a91b61 ad56a771-4633-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172946 https://www.mdpi.com/1999-4923/15/9/2221 1 62b9026f-4633-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172945 Fakulteta za farmacijo 0 0 0