20.500.12556/RUL-148646 Fetal death from SARS-CoV-2 mediated acute placental failure Introduction: We demonstrate the nonlinear severity of symptoms of SARS-CoV-2 infection in the mother leading to fetal death after acute placental failure. Methods: Careful clinical evaluation, real-time RT-PCR molecular microbiologic testing, isolation of a viable virus, and autopsy with histologic results were used to investigate the possible vertical transmission of SARS-CoV-2 infection from mother to fetus. Results: Histologic changes in the placenta correlate with SARS-CoV-2 infection. Total nucleic acid isolated from vaginal swabs, fresh placental tissue, and deparaffinized tissue showed a high viral load of SARS-CoV-2. Complete genome sequencing confirmed the presence of the SARS-CoV-2 Delta variant. Discussion: Several methods have been used to confirm SARS-CoV-2-mediated acute placental failure, all of which were conclusive. It should be noted that careful periodic fetal well-being checks are required in women infected with SARS-CoV-2, regardless of the severity of symptoms. Most of the cases described with fetal death occurred in the third trimester. Covid-19 Delta variant fetal death early embryo implantation SARS-CoV-2 placenta covid-19 smrt ploda različica delta true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-28 13:06:15 2023-08-28 13:06:17 2024-08-28 11:37:00 0000-00-00 00:00:00 2023 0 0 5 str. art. 103958 Vol. 158 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 618.1 1872-7603 10.1016/j.jri.2023.103958 154593539 1-s2.0-S016503782300164X-main.pdf 1-s2.0-S016503782300164X-main.pdf 1 EF114B47B5F82A81C5BE0638D5673812 ff022873765da8ff145efc669482ed0ecdcdc02162afd0f617047b2c54da6aa3 1c72a668-4593-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172930 https://www.sciencedirect.com/science/article/pii/S016503782300164X 0 fec48a6a-4592-11ee-a605-0050569b8976 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172929 Medicinska fakulteta 0 0 0