20.500.12556/RUL-148261 Is obstructive sleep apnea a circadian rhythm disorder? Obstructive sleep apnea is the most common sleep-related breathing disorder worldwide and remains underdiagnosed. Its multiple associated comorbidities contribute to a decreased quality of life and work performance as well as an increased risk of death. Standard treatment seems to have limited effects on cardiovascular and metabolic aspects of the disease, emphasising the need for early diagnosis and additional therapeutic approaches. Recent evidence suggests that the dysregulation of circadian rhythms, processes with endogenous rhythmicity that are adjusted to the environment through various cues, is involved in the pathogenesis of comorbidities. In patients with obstructive sleep apnea, altered circadian gene expression patterns have been demonstrated. Obstructive respiratory events may promote circadian dysregulation through the effects of sleep disturbance and intermittent hypoxia, with subsequent inflammation and disruption of neural and hormonal homeostasis. In this review, current knowledge on obstructive sleep apnea, circadian rhythm regulation, and circadian rhythm sleep disorders is summarised. Studies that connect obstructive sleep apnea to circadian rhythm abnormalities are critically evaluated. Furthermore, pathogenetic mechanisms that may underlie this association, most notably hypoxia signalling, are presented. A bidirectional relationship between obstructive sleep apnea and circadian rhythm dysregulation is proposed. Approaching obstructive sleep apnea as a circadian rhythm disorder may prove beneficial for the development of new, personalised diagnostic, therapeutic and prognostic tools. However, further studies are needed before the clinical approach to obstructive sleep apnea includes targeting the circadian system. obstructive sleep apnea breathing disorder circadian rhythms chronotherapy comorbidities gene expression hypoxia molecular clock sleep disorders obstruktivna apneja v spanju motnja dihanja cirkadiani ritem true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-08 09:11:12 2023-08-08 09:11:20 2023-08-09 03:33:57 0000-00-00 00:00:00 2023 0 0 20 str. iss. 4, art. e13875 Vol. 32 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 616.2 1365-2869 10.1111/jsr.13875 145368323 Journal_of_Sleep_Research_-_2023_-_mon.pdf Journal_of_Sleep_Research_-_2023_-_mon.pdf 1 BCD10025E66C98CEA4AAEACFA4226637 249b48f8f8aa8213381aa50c7966449fb37295d5f1921f47a454a487f4821ce7 a6a5cf96-35bb-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172327 https://onlinelibrary.wiley.com/doi/10.1111/jsr.13875 0 9bf2a70e-35bb-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172326 Medicinska fakulteta 0 0 0