20.500.12556/RUL-148208 Cathepsin C structure, function, and pharmacological targeting Cathepsin C is a papain-like cysteine peptidase known primarily for its involvement in the activation of serine peptidases in neutrophils and other immune cells. Its critical role in this process qualifies cathepsin C as a target for the treatment of inflammatory diseases, and its most advanced inhibitor, brensocatib (Insmed), is currently in phase 3 clinical trials for the treatment of non-cystic fibrosis bronchiectasis. Beyond neutrophils, its importance is highlighted by loss-of-function mutations that cause the recessively inherited Papillon-Lefèvre syndrome. At the molecular level, cathepsin C has several structural and functional features that set it apart from other members of the family and enable its selective targeting. It possesses dipeptidyl-peptidase activity (its other common name is dipeptidyl-peptidase I) due to the presence of an additional exclusion domain that also controls its stepwise tetramerization during maturation. In this review article, we summarize the current state of the art regarding the biochemical properties of cathepsin C, its physiological and pathological roles in neutrophils and beyond, and recent advances in the development and evaluation of cathepsin C inhibitors. dipeptidyl-peptidase I DPPI cysteine catepsin bronchiectasis brensocatib dipeptidil-peptidaza I DPPI cisteinski katepsin bronhiektazija brensocatib true false true Angleški jezik Slovenski jezik Članek v reviji 2023-08-02 07:58:35 2023-08-02 07:58:36 2023-08-03 03:34:22 0000-00-00 00:00:00 2023 0 0 Str. 1-17 iss. 3, art. 14 Vol. 2 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 2023-01-01 547.112 2771-2893 10.20517/rdodj.2023.09 160356355 rdodj2009.pdf rdodj2009.pdf 1 10021AB84E4999F03112C483601D1288 23891ca4c27642e7560a6e7787e6c562967924265a8d6473a192bedc8812bcc1 1f032036-30fa-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172226 https://rdodjournal.com/article/view/5974 1 a46cb34f-30f9-11ee-aeaf-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=172225 Fakulteta za kemijo in kemijsko tehnologijo 0 0 0