20.500.12556/RUL-147025 Sinteza analogov deksrazoksana kot zaviralcev človeške DNA-topoizomeraze II Synthesis of dexrazoxane analogues as human DNA topoisomerase II inhibitors V sklopu magistrske naloge smo sintetizirali in ovrednotili nekaj novih analogov deksrazoksana, kot potencialnih zaviralcev človeške DNA-topoizomeraze II. Pri večini načrtovanih spojin smo strukturne spremembe želeli uvesti na osrednji propan-1,2-diilni fragment, ki v molekuli deksrazoksana povezuje dva piperazin-2,6-dionska heterocikla. Pripraviti smo želeli dve spojini, ki imata na osrednjem delu namesto metilne skupine vezano pentilno skupino ali fenilni obroč, vendar žal zadnja stopnja sinteze ni bila uspešna. Uspešno pa smo pripravili spojino 11, ki ima namesto obeh piperazin-2,6-dionskih heterociklov vezana piperazin-2-onska obroča, ki sta povezana z 1-oksoetan-1,2-diilnim povezovalcem. Vse nove spojine smo fizikalno-kemijsko ovrednotili, s čemer smo potrdili njihovo identiteto in čistost. In our master's thesis, we synthesised and evaluated some new dexrazoxane analogues as potential inhibitors of human DNA topoisomerase II. For most of the proposed compounds, we wanted to make structural changes to the central propane-1,2-diyl that links the two piperazine-2,6-dione heterocycles in the dexrazoxane molecule. We wanted to prepare two compounds that have a pentyl group or a phenyl ring in the central part instead of a methyl group, but unfortunately the last step of the synthesis was not successful. However, we successfully prepared compound 11 containing piperazine-2,6-dione heterocycles instead of the two piperazine-2,6-dione heterocycles linked with a 1-oxoethane-1,2-diyl linker. We have physicochemically investigated all new compounds and confirmed their identity and purity. deksrazoksan DNA-topoizomeraza II protirakava učinkovina zaviralec dexrazoxane DNA-topoisomerase II antitumor agent inhibitor true false false Slovenski jezik Angleški jezik Magistrsko delo/naloga 2023-06-21 07:45:03 2023-06-21 07:45:08 2023-06-22 03:37:28 0000-00-00 00:00:00 2023 0 0 0000-00-00 NiDoloceno NiDoloceno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 1970-01-01 95248 14235.pdf 14235.pdf 1 183DC0793C64A58F7825EEDFC9403FD6 9582587e3bc730b50844612a9b8908af107153e9df1cb8aa9275c26e59249e4c 6e45d789-0ff6-11ee-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=170371 Fakulteta za farmacijo 0 0 0