20.500.12556/RUL-145899 Comparing the effects of encapsulated and non-encapsulated propolis extracts on model lipid membranes and lactic bacteria, with emphasis on the synergistic effects of its various compounds Propolis is a resinous compound made by bees with well-known biological activity. However, comparisons between encapsulated and non-encapsulated propolis are lacking. Therefore, the antibacterial activity, effect on the phase transition of lipids, and inhibition of UV-induced lipid oxidation of the two forms of propolis were compared. The results showed that non-encapsulated propolis produces quicker effects, thus being better suited when more immediate effects are required (e.g., antibacterial activity). In order to gain an in-depth introspective on these effects, we further studied the synergistic effect of propolis compounds on the integrity of lipid membranes. The knowledge of component synergism is important for the understanding of effective propolis pathways and for the perspective of modes of action of synergism between different polyphenols in various extracts. Thus, five representative molecules, all previously isolated from propolis (chrysin, quercetin, trans-ferulic acid, caffeic acid, (-)-epigallocatechin-3-gallate) were mixed, and their synergistic effects on lipid bilayers were investigated, mainly using DSC. The results showed that some compounds (quercetin, chrysin) exhibit synergism, whereas others (caffeic acid, t-ferulic acid) do not show any such effects. The results also showed that the synergistic effects of mixtures composed from several different compounds are extremely complex to study, and that their prediction requires further modeling approaches. liposomes lipid phase transition chrysin quercetin (-)-epigallocatechin-3-gallate transferulic acid caffeic acid UV-oxidation propolis kapsulacija modelne lipidne membrane fenolne spojine epigalokatehin epigalokatehin-3-galat interakcije true false true Angleški jezik Slovenski jezik Članek v reviji 2023-05-17 13:28:32 2023-05-17 13:28:33 2023-05-18 04:00:40 0000-00-00 00:00:00 2023 0 0 21 str. iss. 2 Vol. 28 2023 0000-00-00 Zaloznikova Objavljeno NiDoloceno 0000-00-00 0000-00-00 0000-00-00 577.352:638.135:547.56 1420-3049 10.3390/molecules28020712 137197827 RAZ_Sturm_Luka_2023.pdf RAZ_Sturm_Luka_2023.pdf 1 2D9BD5BBCC24DA8C1B9D6D0B5163611A d5678bcdac958bb1773878b276ce7f7bfc543d644006d72dde2e436187a66043 8852b952-f4a6-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168979 https://www.mdpi.com/1420-3049/28/2/712 1 b305d1a2-f4a5-11ed-a314-00155dcfd717 https://repozitorij.uni-lj.si/Dokument.php?lang=slv&id=168978 Biotehniška fakulteta 0 0 0